Select a medication above to begin.
sumatriptan/ naproxen sodium
generic
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, incl. MI and stroke; risk may occur early in tx and may incr. w/ duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events incl. bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and w/o warning sx; elderly pts and pts w/ hx of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: TAB: 85 mg/500 mg
migraine, acute
- [1 tab PO x1]
- Max: 2 tabs/24h; Info: may repeat dose x1 after at least 2h; do not cut/crush/chew tab; give w/ food if GI upset occurs
renal dosing
- [see below]
- CrCl >89: no adjustment; CrCl 30-89: not defined, caution advised; CrCl <30: avoid use; advanced renal dz: avoid use
- HD/PD: avoid use
hepatic dosing
- [see below]
- mild-moderate impairment: avoid use, dose adjustment not possible w/ fixed-dose combo; severe impairment: contraindicated
Peds Dosing .
- Dosage forms: TAB: 85 mg/500 mg
migraine, acute
- [12-17 yo]
- Dose: 1 tab PO x1; Max: 1 tab/24h; Info: do not cut/crush/chew tab; give w/ food if GI upset occurs
renal dosing
- [see below]
- CrCl >89: no adjustment; CrCl 30-89: not defined, caution advised; CrCl <30: avoid use; advanced renal dz: avoid use
- HD/PD: avoid use
hepatic dosing
- [see below]
- mild-moderate impairment: avoid use, dose adjustment not possible w/ fixed-dose combo; severe impairment: contraindicated