Select a medication above to begin.
Cimzia
certolizumab pegol
Black Box Warnings .
Serious Infection Risk
weigh tx benefit vs. risk in pts w/ chronic or recurrent infection; pulmonary and extrapulmonary tuberculosis (TB), invasive fungal infections, and other opportunistic infections incl. Legionella and Listeria observed; some infections have been fatal; most infections occur in combo w/ other immunosuppressants; evaluate for TB risk factors and screen for latent TB infection before and during certolizumab tx; initiate anti-TB tx before certolizumab tx; monitor for infection s/sx during and after certolizumab tx; since active TB has developed in pts w/ negative tuberculin skin test, monitor all pts for active TB s/sx; since histoplasmosis may be present in pts w/ negative antigen and antibody tests, consider empiric antifungal tx in pts w/ severe systemic illness if at risk for invasive fungal infection; D/C certolizumab tx if serious infection or sepsis occurs
Malignancy
lymphoma and other malignancies, some fatal, reported in children and adolescents treated w/ TNF blockers
Adult Dosing .
Dosage forms: INJ (pre-filled syringe): 200 mg per mL; INJ (vial): 200 mg per mL
Crohn dz, mod-severe
- [400 mg SC q4wk]
- Start: 400 mg SC x1 on wk 0, 2, 4
rheumatoid arthritis, mod-severe
- [200 mg SC q2wk or 400 mg SC q4wk]
- Start: 400 mg SC x1 on wk 0, 2, 4
psoriatic arthritis
- [200 mg SC q2wk or 400 mg SC q4wk]
- Start: 400 mg SC x1 on wk 0, 2, 4
ankylosing spondylitis
- [200 mg SC q2wk or 400 mg SC q4wk]
- Start: 400 mg SC x1 on wk 0, 2, 4
axial spondyloarthritis, non-radiographic
- [200 mg SC q2wk or 400 mg SC q4wk]
- Start: 400 mg SC x1 on wk 0, 2, 4
plaque psoriasis, mod-severe
- [400 mg SC q2wk]
- Info: if wt <90 kg, may consider 400 mg SC x1 on wk 0, 2, 4, then 200 mg SC q2wk
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ (pre-filled syringe): 200 mg per mL; INJ (vial): 200 mg per mL
polyarticular juvenile idiopathic arthritis
- [2 yo and older, 10-19.9 kg]
- Dose: 50 mg SC q2wk; Start: 100 mg SC x1 on wk 0, 2, 4
- [2 yo and older, 20-39.9 kg]
- Dose: 100 mg SC q2wk; Start: 200 mg SC x1 on wk 0, 2, 4
- [2 yo and older, >40 kg]
- Dose: 200 mg SC q2wk; Start: 400 mg SC x1 on wk 0, 2, 4
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]