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alvimopan
generic
Black Box Warnings .
Appropriate Use
alvimopan available only through restricted program for short-term use (15 doses) in hospitalized pts; hospitals must be registered and meet all requirements for Alvimopan REMS program
Myocardial Infarction Risk
incr. MI incidence during 12mo study w/ alvimopan compared to placebo, although causal relationship not established; no incr. MI risk observed in short-term study
Adult Dosing .
Dosage forms: CAP: 12 mg
Restricted Distribution in US
- [1-800-278-0340 or www.alvimopanREMS.com for more info]
ileus, postop
- [12 mg PO bid for up to 7 days]
- Start: 12 mg PO x1 30min-5h before surgery; Max: 15 doses; Info: start bid dosing the day after surgery
renal dosing
- [see below]
- renal impairment: no adjustment; ESRD: avoid use; Info: metabolite accumulation possible in severe impairment w/ multiple doses
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class C: avoid use
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.