Select a medication above to begin.
Celebrex
celecoxib
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, incl. MI and stroke; risk may occur early in tx and may incr. w/ duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events incl. bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and w/o warning sx; elderly pts and pts w/ hx of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: CAP: 50 mg, 100 mg, 200 mg, 400 mg
osteoarthritis
- [200 mg PO qd]
- Alt: 100 mg PO bid; Info: use lowest effective dose, shortest effective tx duration; consider starting at 50% of lowest dose in CYP2C9 poor metabolizers; give w/ food if GI upset occurs
rheumatoid arthritis
- [100-200 mg PO bid]
- Info: use lowest effective dose, shortest effective tx duration; consider starting at 50% of lowest dose in CYP2C9 poor metabolizers; give w/ food if GI upset occurs
ankylosing spondylitis
- [200 mg PO qd]
- Max: 400 mg/day; Alt: 100 mg PO bid; Info: use lowest effective dose, shortest effective tx duration; may incr. dose to 400 mg/day if no response after 6wk; consider D/C if no response to max dose after 6wk; consider starting at 50% of lowest dose in CYP2C9 poor metabolizers; give w/ food if GI upset occurs
dysmenorrhea
- [200 mg PO bid]
- Start: 400 mg PO x1, may give additional 200 mg on day 1 if needed; Info: use lowest effective dose, shortest effective tx duration; consider starting at 50% of lowest dose in CYP2C9 poor metabolizers; give w/ food if GI upset occurs
pain, acute
- [200 mg PO bid]
- Start: 400 mg PO x1, may give additional 200 mg on day 1 if needed; Info: use lowest effective dose, shortest effective tx duration; consider starting at 50% of lowest dose in CYP2C9 poor metabolizers; give w/ food if GI upset occurs
renal dosing
- [see below]
- CrCl >60: no adjustment; CrCl 30-60: not defined, caution advised; CrCl <30: avoid use; advanced renal dz: avoid use
- HD/PD: avoid use
hepatic dosing
- [see below]
- Child-Pugh Class B: decr. usual dose by 50%; Child-Pugh Class C: avoid use
Peds Dosing .
- Dosage forms: CAP: 50 mg, 100 mg
juvenile idiopathic arthritis
- [2 yo and older, 10-25 kg]
- Dose: 50 mg PO bid; Info: use lowest effective dose, shortest effective tx duration; consider alternative tx in CYP2C9 poor metabolizers; give w/ food if GI upset occurs
- [2 yo and older, >25 kg]
- Dose: 100 mg PO bid; Info: use lowest effective dose, shortest effective tx duration; consider alternative tx in CYP2C9 poor metabolizers; give w/ food if GI upset occurs
renal dosing
- [see below]
- CrCl >60: no adjustment; CrCl 30-60: not defined, caution advised; CrCl <30: avoid use; advanced renal dz: avoid use
- HD/PD: avoid use
hepatic dosing
- [see below]
- Child-Pugh Class B: decr. usual dose by 50%; Child-Pugh Class C: avoid use