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Aplenzin
bupropion hydrobromide
Black Box Warnings .
Suicidality
incr. suicidality risk in children, adolescents, and young adults w/ major depressive or other psychiatric disorders; weigh risk vs. benefit; in short-term studies of antidepressants vs. placebo, suicidality risk not incr. in pts >24 yo, and risk decr. in pts 65 yo and older; depression and certain other psychiatric disorders themselves assoc. w/ incr. suicide risk; observe all pts for clinical worsening, suicidality, or unusual behavior changes; advise families and caregivers of need for close observation and communication w/ prescriber; not approved for peds use
Adult Dosing .
Dosage forms: ER TAB: 174 mg, 348 mg, 522 mg
Special Note
- [strength clarification]
- Info: bupropion HBr 174, 348, 522 mg = bupropion HCl 150, 300, 450 mg
major depressive disorder
- [348 mg PO qam]
- Start: 174 mg PO qam, may incr. to 348 mg PO qam after 4 days; Max: 522 mg/day; Info: decr. dose to 174 mg/day x2wk to D/C; do not cut/crush/chew tab
seasonal affective disorder
- [348 mg PO qam x4-6mo/year]
- Start: 174 mg PO qam, may incr. to 348 mg PO qam after 7 days; Max: 348 mg/day; Info: begin tx in Sep-Nov, continue until early spring; decr. dose to 174 mg/day x2wk to D/C; do not cut/crush/chew tab
renal dosing
- [see below]
- renal impairment: consider decr. usual dose and/or frequency; Info: ER form cannot be cut, consider IR form for dose adjustments
- HD/PD: not defined
hepatic dosing
- [see below]
- mild impairment: consider decr. usual dose and/or frequency; moderate-severe impairment: max 174 mg q48h
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.