Select a medication above to begin.
Celexa
citalopram
Black Box Warnings .
Suicidality
antidepressants incr. suicidality risk in peds and young adult pts in short-term studies; monitor closely for clinical worsening and suicidality; advise families and caregivers of need for close observation and communication w/ prescriber; not approved for peds pts
Adult Dosing .
Dosage forms: TAB: 10 mg, 20 mg, 40 mg
major depressive disorder
- [20-40 mg PO qd]
- Start: 20 mg PO qd, may incr. dose after at least 1wk; Max: 40 mg/day; Info: max 20 mg/day in CYP2C19 poor metabolizers and pts >60 yo; taper dose gradually to D/C
obsessive-compulsive disorder (off-label)
- [40-60 mg PO qd]
- Start: 20 mg PO qd, incr. by 20 mg/day qwk; Max: 60 mg/day; Info: max 20 mg/day in CYP2C19 poor metabolizers and pts >60 yo; taper dose gradually to D/C
vasomotor sx, mod-severe menopausal (off-label)
- [10-20 mg PO qd]
- Start: 10 mg PO qd, may incr. to 20 mg PO qd after at least 1wk; Info: max 20 mg/day in CYP2C19 poor metabolizers and pts >60 yo; taper dose gradually to D/C
renal dosing
- [see below]
- CrCl >20: no adjustment; CrCl <20: not defined
- HD/PD: not defined
hepatic dosing
- [adjust dose amount]
- hepatic impairment: max 20 mg/day
Peds Dosing .
- Dosage forms: TAB: 10 mg, 20 mg, 40 mg
major depressive disorder (off-label)
- [7-11 yo]
- Dose: 20-40 mg PO qd; Start: 10 mg PO qd, incr. by 5 mg/day q2wk; Max: 40 mg/day; Info: max 20 mg/day in CYP2C19 poor metabolizers; taper dose gradually to D/C
- [12 yo and older]
- Dose: 20-40 mg PO qd; Start: 20 mg PO qd, may incr. by 10 mg/day q2wk; Max: 40 mg/day; Info: max 20 mg/day in CYP2C19 poor metabolizers; taper dose gradually to D/C
generalized anxiety disorder (off-label)
- [7-17 yo]
- Dose: 10-40 mg PO qd; Start: 5-10 mg PO qd, may incr. dose q2-4wk; Max: 40 mg/day; Info: max 20 mg/day in CYP2C19 poor metabolizers; taper dose gradually to D/C
obsessive-compulsive disorder (off-label)
- [7-12 yo]
- Dose: 10-60 mg PO qd; Start: 2.5-10 mg PO qd, may incr. by 5 mg/day q3wk; Max: 60 mg/day; Info: max 20 mg/day in CYP2C19 poor metabolizers; taper dose gradually to D/C
- [13 yo and older]
- Dose: 10-60 mg PO qd; Start: 10-20 mg PO qd, may incr. by 10 mg/day q3wk; Max: 60 mg/day; Info: max 20 mg/day in CYP2C19 poor metabolizers; taper dose gradually to D/C
intermittent explosive disorder (off-label)
- [7-17 yo]
- Dose: 10-40 mg PO qd; Start: 10 mg PO qd, may incr. by 10 mg/day qwk; Max: 40 mg/day; Info: max 20 mg/day in CYP2C19 poor metabolizers; taper dose gradually to D/C
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: not defined
hepatic dosing
- [not defined]
- hepatic impairment: consider adult hepatic dosing for guidance