Afinitor

Adult Dosing .

Dosage forms:  TAB: 2.5 mg, 5 mg, 7.5 mg, 10 mg

Special Note

[formulation clarification]

Info: Afinitor not interchangeable w/ Afinitor Disperz; do not substitute on a mg to mg basis

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments; D/C >1wk before elective surgery, restart >2wk after major surgery when wound fully healed

hormone receptor-positive HER2-negative breast CA, advanced

[10 mg PO qd]

Info: for postmenopausal pts who have failed letrozole or anastrozole; use w/ exemestane; give consistently w/ food or empty stomach; do not cut/crush/chew tab

neuroendocrine tumors, progressive

[10 mg PO qd]

Info: for pts w/ unresectable, locally advanced or metastatic tumors of pancreatic, GI, or lung origin; give consistently w/ food or empty stomach; do not cut/crush/chew tab

renal cell CA, advanced

[monotherapy]

Dose: 10 mg PO qd; Info: for pts who have failed sunitinib or sorafenib; give consistently w/ food or empty stomach; do not cut/crush/chew tab

[combo w/ lenvatinib]

Dose: 5 mg PO qd; Info: for pts who have received 1 prior antiangiogenic tx; give consistently w/ food or empty stomach; do not cut/crush/chew tab

renal angiomyolipoma, tuberous sclerosis complex-associated

[10 mg PO qd]

Info: for pts not requiring immediate surgery; give consistently w/ food or on empty stomach; do not cut/crush/chew tab

subependymal giant cell astrocytoma, tuberous sclerosis complex-associated

[individualize dose PO qd]

Start: 4.5 mg/m^2/dose PO qd; Info: for pts who cannot be curatively resected; may adjust dose by up to 5 mg/day q1-2wk based on trough levels; give consistently w/ food or on empty stomach; do not cut/crush/chew tab

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[tuberous sclerosis complex-associated subependymal giant cell astrocytoma]

Child-Pugh Class C: start 2.5 mg/m^2/dose qd

[all other indications]

Child-Pugh Class A: 7.5 mg qd, may decr. dose to 5 mg qd if not tolerated; Child-Pugh Class B: 5 mg qd, may decr. dose to 2.5 mg qd if not tolerated; Child-Pugh Class C: 2.5 mg qd, weigh risk/benefit

Peds Dosing .

Dosage forms:  TAB: 2.5 mg, 5 mg, 7.5 mg, 10 mg

Special Note

[formulation clarification]

Info: Afinitor not interchangeable w/ Afinitor Disperz; do not substitute on a mg to mg basis

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments; D/C >1wk before elective surgery, restart >2wk after major surgery when wound fully healed

subependymal giant cell astrocytoma, tuberous sclerosis complex-associated

[1 yo and older]

Dose: individualize dose PO qd; Start: 4.5 mg/m^2/dose PO qd; Info: for pts who cannot be curatively resected; may adjust dose by up to 5 mg/day q1-2wk based on trough levels; give consistently w/ food or on empty stomach; do not cut/crush/chew tab

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[adjust dose amount]

Child-Pugh Class C: start 2.5 mg/m^2/dose qd