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GamaSTAN S/ D
immune globulin (human)
Black Box Warnings .
Thrombosis
may occur w/ immune globulin products; risk factors incl. advanced age, prolonged immobilization, hypercoagulable conditions, venous or arterial thrombosis hx, estrogen use, indwelling central vascular catheter, hyperviscosity, and cardiovascular dz risk; thrombosis may occur in pts w/o risk factors; ensure adequate hydration before admin; monitor for s/sx thrombosis and assess blood viscosity in pts w/ hyperviscosity risk
Adult Dosing .
Dosage forms: INJ
hepatitis A prophylaxis
- [pre-exposure, travel duration <1mo]
- Dose: 0.1 mL/kg/dose IM x1; Info: may give w/ hepatitis A vaccine if pts >40 yo, immunocompromised, chronic liver dz, close contacts, occupational risk; see CDC Pre-Travel Vaccine recommendations in Guidelines > Specialties > Infectious Diseases
- [pre-exposure, travel duration >1mo]
- Dose: 0.2 mL/kg/dose IM x1; Info: may give w/ hepatitis A vaccine if pts >40 yo, immunocompromised, chronic liver dz, close contacts, occupational risk; repeat dose q2mo if cont. exposure or until vaccinated; see CDC Pre-Travel Vaccine recommendations in Guidelines > Specialties > Infectious Diseases
- [post-exposure]
- Dose: 0.1 mL/kg/dose IM x1 w/in 14 days of exposure; Info: may give w/ hepatitis A vaccine in pts >40 yo; give w/ hepatitis A vaccine if immunocompromised, chronic liver dz, close contacts, occupational risk
measles prophylaxis
- [0.25 mL/kg/dose IM x1 w/in 6 days of exposure]
varicella prophylaxis
- [0.6-1.2 mL/kg/dose IM x1]
- Start: ASAP after exposure; Info: give if varicella zoster immune globulin unavailable
rubella prophylaxis
- [0.55 mL/kg/dose IM x1]
- Info: for pregnant pts who will not consider pregnancy termination
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ
hepatitis A prophylaxis (off-label)
- [pre-exposure, travel duration <1mo]
- Dose: 0.1 mL/kg/dose IM x1; Info: may give w/ hepatitis A vaccine in pts 12 mo and older if immunocompromised, chronic liver dz, close contacts, occupational risk; see CDC Pre-Travel Vaccine recommendations in Guidelines > Specialties > Infectious Diseases
- [pre-exposure, travel duration >1mo]
- Dose: 0.2 mL/kg/dose IM x1; Info: repeat dose q2mo if cont. exposure or until vaccinated; may give w/ hepatitis A vaccine in pts 12 mo and older if immunocompromised, chronic liver dz, close contacts, occupational risk; see CDC Pre-Travel Vaccine recommendations in Guidelines > Specialties > Infectious Diseases
- [post-exposure]
- Dose: 0.1 mL/kg/dose IM x1 w/in 14 days of exposure; Info: give w/ hepatitis A vaccine in pts 12 mo and older if immunocompromised, chronic liver dz, close contacts, occupational risk
measles prophylaxis (off-label)
- [immunocompetent pts]
- Dose: 0.25 mL/kg/dose IM x1 w/in 6 days of exposure; Max: 15 mL/dose
- [immunocompromised pts]
- Dose: 0.5 mL/kg/dose IM x1 w/in 6 days of exposure; Max: 15 mL/dose
varicella prophylaxis (off-label)
- [0.6-1.2 mL/kg/dose IM x1]
- Start: ASAP after exposure; Info: give if varicella zoster immune globulin unavailable
rubella prophylaxis (off-label)
- [0.55 mL/kg/dose IM x1]
- Info: for pregnant pts who will not consider pregnancy termination
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]