naltrexone

Adult Dosing .

Dosage forms:  TAB: 50 mg

Special Note

[prescribing info]

Info: consider prescribing naloxone in pts w/ opioid use disorder

opioid dependence

[50 mg PO qd]

Start: 25 mg PO qd x1-2 days; Alt: 350 mg/wk PO divided 3x/wk; Info: not 1st-line tx; must be opioid free x7-14 days before tx start; consider naloxone challenge test if risk of withdrawal suspected

alcohol dependence

[50 mg PO qd]

Info: must be opioid free x7-14 days before tx start; consider naloxone challenge test if risk of withdrawal suspected

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined, caution advised

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  TAB: 50 mg

Special Note

[prescribing info]

Info: consider prescribing naloxone in pts w/ opioid use disorder

opioid dependence (off-label)

[adolescents]

Dose: 50 mg PO qd; Start: 25 mg PO qd x1-2 days; Info: not 1st-line tx; must be opioid free x7-14 days before tx start; consider naloxone challenge test if risk of withdrawal suspected

alcohol dependence (off-label)

[adolescents]

Dose: 50 mg PO qd; Info: must be opioid free x7-14 days before tx start; consider naloxone challenge test if risk of withdrawal suspected

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined, caution advised

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance