carvedilol

Adult Dosing .

Dosage forms:  TAB: 3.125 mg, 6.25 mg, 12.5 mg, 25 mg; ER CAP: 10 mg, 20 mg, 40 mg, 80 mg

HTN

[IR form]

Dose: 6.25-25 mg PO bid; Start: 6.25 mg PO bid, may double dose q1-2wk; Max: 50 mg/day; Info: give w/ food; taper dose over 1-2wk to D/C

[ER form, initial tx]

Dose: 20-80 mg ER PO qam; Start: 20 mg ER PO qam, may double dose q1-2wk; Max: 80 mg/day ER; Info: give w/ food; may open cap, but do not crush/chew/dissolve contents; taper dose over 1-2wk to D/C

[ER form, conversion from IR form]

Dose: 20-80 mg ER PO qam; Max: 80 mg/day ER; Info: 6.25 mg/day IR = 10 mg/day ER; may incr. dose q1-2wk; in pts 65 yo and older or at risk of hypotension, dizziness, or syncope on 25 mg/day IR or 50 mg/day IR, switch to 20 mg/day ER or 40 mg/day ER, respectively, then may incr. dose q2wk; give w/ food; may open cap, but do not crush/chew/dissolve contents; taper dose over 1-2wk to D/C

heart failure w/ reduced ejection fraction

[IR form]

Dose: 25-50 mg PO bid; Start: 3.125 mg PO bid, may double dose q2wk; Max: 50 mg/day; 100 mg/day if >85 kg; Info: minimize fluid retention prior to tx; give w/ food; taper dose over 1-2wk to D/C

[ER form, initial tx]

Dose: 80 mg ER PO qam; Start: 10 mg ER PO qam, may double dose q2wk; Max: 80 mg/day ER; Info: minimize fluid retention prior to tx; give w/ food; may open cap, but do not crush/chew/dissolve contents; taper dose over 1-2wk to D/C

[ER form, conversion from IR form]

Dose: 80 mg ER PO qam; Max: 80 mg/day ER; Info: 6.25 mg/day IR = 10 mg/day ER; may incr. dose q2wk; in pts 65 yo and older or at risk of hypotension, dizziness, or syncope on 25 mg/day IR or 50 mg/day IR, switch to 20 mg/day ER or 40 mg/day ER, respectively, then may incr. dose q2wk; minimize fluid retention prior to tx; give w/ food; may open cap, but do not crush/chew/dissolve contents; taper dose over 1-2wk to D/C

left ventricular dysfxn, post-MI

[IR form]

Dose: 25 mg PO bid; Start: 6.25 mg PO bid ASAP after pt stable, then double dose q3-10 days; Info: minimize fluid retention prior to tx; start 3.125 mg PO bid and/or titrate slower if fluid retention, hypotension, or bradycardia; give w/ food; taper dose over 1-2wk to D/C

[ER form, initial tx]

Dose: 80 mg ER PO qam; Start: 20 mg ER PO qam ASAP after pt stable, then double dose q3-10 days; Info: minimize fluid retention prior to tx; start 10 mg ER PO qam and/or titrate slower if fluid retention, hypotension, or bradycardia; give w/ food; may open cap, but do not crush/chew/dissolve contents; taper dose over 1-2wk to D/C

[ER form, conversion from IR form]

Dose: 80 mg ER PO qam; Info: 6.25 mg/day IR = 10 mg/day ER; incr. dose q3-10 days; in pts 65 yo and older or at risk of hypotension, dizziness, or syncope on 25 mg/day IR or 50 mg/day IR, switch to 20 mg/day ER or 40 mg/day ER, respectively, then incr. dose q2wk; minimize fluid retention prior to tx; give w/ food; may open cap, but do not crush/chew/dissolve contents; taper dose over 1-2wk to D/C

atrial fibrillation/flutter (off-label)

[3.125-25 mg PO bid]

Alt: 3.125-50 mg PO bid; Info: for maintenance rate control; give w/ food; taper dose over 1-2wk to D/C

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: avoid use

Peds Dosing .

Dosage forms:  TAB: 3.125 mg, 6.25 mg, 12.5 mg, 25 mg

heart failure w/ reduced ejection fraction (off-label)

[1-23 mo]

Dose: 0.2-3 mg/kg/day PO divided bid-tid; Start: 0.05 mg/kg/day divided bid-tid, may incr. dose q2wk; Max: 3 mg/kg/day; Info: minimize fluid retention prior to tx; give w/ food; taper dose over 1-2wk to D/C

[2-11 yo]

Dose: 0.2-2 mg/kg/day PO divided bid; Start: 0.05 mg/kg/day divided bid, may incr. dose q2wk; Max: 2 mg/kg/day; Info: minimize fluid retention prior to tx; give w/ food; taper dose over 1-2wk to D/C

[12 yo and older]

Dose: 0.2-1 mg/kg/day PO divided bid; Start: 0.05 mg/kg/day divided bid, may incr. dose q2wk; Max: 50 mg/day; Info: minimize fluid retention prior to tx; give w/ food; taper dose over 1-2wk to D/C

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance