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Rhophylac
Rho(D) immune globulin
Black Box Warnings .
Intravascular Hemolysis in Immune Thrombocytopenic Purpura (ITP)
cases of intravascular hemolysis (IVH) leading to severe anemia, multi-system organ failure, ARDS, renal insufficiency or failure, DIC, and death have been reported in ITP pts treated w/ intravenous Rho(D) immune globulin products; monitor ITP pts closely in health care setting for at least 8h after admin; obtain dipstick urinalysis at baseline, 2h and 4h after admin. and prior to end of monitoring period; alert pts to s/sx of IVH incl. back pain, rigors, fever, or hematuria; if IVH present or suspected, obtain post-tx tests incl. Hgb, haptoglobin, LDH and bilirubin; use Rh-negative RBC if transfusion required post-tx
Adult Dosing .
Dosage forms: INJ
Special Note
- [strength clarification]
- Info: doses expressed in mcg; 1 mcg = 5 international units
Rh-incompatible pregnancy
- [routine prophylaxis]
- Dose: 300 mcg IM/IV x1 at 28-30 wk gestation, then 300 mcg IM/IV x1 w/in 72h of delivery
- [fetomaternal hemorrhage risk]
- Dose: 300 mcg IM/IV x1 w/in 72h of obstetrical complication or invasive procedure
- [excessive fetomaternal hemorrhage]
- Dose: 300 mcg IM/IV x1 w/in 72h of exposure, then 20 mcg/mL of RBC exposure exceeding 15 mL IM/IV x1 w/in 72h of exposure; Info: if excessive bleeding cannot be quantified, give 600 mcg IM/IV x1 w/in 72h of exposure
Rh-incompatible transfusion
- [20 mcg/mL of RBC exposure IM/IV x1 w/in 72h of exposure]
- Alt: 20 mcg/2 mL of whole blood exposure IM/IV x1 w/in 72h of exposure
idiopathic thrombocytopenic purpura
- [50 mcg/kg/dose IV x1]
- Info: for Rh-positive, non-splenectomized pts
renal dosing
- [IM route]
- renal impairment: not defined
- HD/PD: not defined
- [IV route]
- renal impairment: not defined, caution advised; Info: use minimum infusion rate practicable
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.