Select a medication above to begin.
Caldolor
ibuprofen
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, incl. MI and stroke; risk may occur early in tx and may incr. w/ duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events incl. bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and w/o warning sx; elderly pts and pts w/ hx of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: INJ
pain
- [400-800 mg IV q6h prn]
- Max: 3200 mg/day; Info: use lowest effective dose, shortest effective tx duration; may use w/ opioids for moderate-severe pain
fever
- [400 mg IV q4-6h prn]
- Max: 3200 mg/day; Alt: 400 mg IV x1, then 100-200 mg IV q4h prn; Info: use lowest effective dose, shortest effective tx duration
renal dosing
- [see below]
- CrCl >60: no adjustment; CrCl 30-60: not defined, caution advised; CrCl <30: avoid use
- HD/PD: avoid use
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: INJ
pain
- [3-5 mo]
- Dose: 10 mg/kg/dose IV x1; Max: 10 mg/kg/dose up to 100 mg/dose; Info: may use w/ opioids for moderate-severe pain
- [6 mo-11 yo]
- Dose: 10 mg/kg/dose IV q4-6h prn; Max: 400 mg/dose; 40 mg/kg/day up to 2400 mg/day; Info: use lowest effective dose, shortest effective tx duration; may use w/ opioids for moderate-severe pain
- [12-17 yo]
- Dose: 400 mg IV q4-6h prn; Max: 40 mg/kg/day up to 2400 mg/day; Info: use lowest effective dose, shortest effective tx duration; may use w/ opioids for moderate-severe pain
fever
- [3-5 mo]
- Dose: 10 mg/kg/dose IV x1; Max: 10 mg/kg/dose up to 100 mg/dose
- [6 mo-11 yo]
- Dose: 10 mg/kg/dose IV q4-6h prn; Max: 400 mg/dose; 40 mg/kg/day up to 2400 mg/day; Info: use lowest effective dose, shortest effective tx duration
- [12-17 yo]
- Dose: 400 mg IV q4-6h prn; Max: 40 mg/kg/day up to 2400 mg/day; Info: use lowest effective dose, shortest effective tx duration
renal dosing
- [see below]
- CrCl >60: no adjustment; CrCl 30-60: not defined, caution advised; CrCl <30: avoid use
- HD/PD: avoid use
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised