Saphris

Adult Dosing .

Dosage forms:  SL TAB: 2.5 mg, 5 mg, 10 mg

schizophrenia

[acute tx]

Dose: 5 mg SL bid; Max: 20 mg/day; Info: D/C if ANC <1000; consider D/C if unexplained decr. in WBC; do not cut/crush/chew tab

[maintenance tx]

Dose: 5-10 mg SL bid; Start: 5 mg SL bid, may incr. to 10 mg SL bid after 1wk; Max: 20 mg/day; Info: periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; do not cut/crush/chew tab

bipolar I disorder, acute manic/mixed

[monotherapy]

Dose: 5-10 mg SL bid; Max: 20 mg/day; Info: periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; do not cut/crush/chew tab

[valproate or lithium adjunct]

Dose: 5-10 mg SL bid; Start: 5 mg SL bid; Max: 20 mg/day; Info: periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; do not cut/crush/chew tab

bipolar I disorder, maintenance tx

[monotherapy]

Dose: 5-10 mg SL bid; Max: 20 mg/day; Info: periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; do not cut/crush/chew tab

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class C: contraindicated

Peds Dosing .

Dosage forms:  SL TAB: 2.5 mg, 5 mg, 10 mg

bipolar I disorder, acute manic/mixed

[monotherapy, 10-17 yo]

Dose: 2.5-10 mg SL bid; Start: 2.5 mg SL bid x3 days, may incr. to 5 mg SL bid x3 days, then may incr. to 10 mg SL bid; Max: 20 mg/day; Info: periodically reassess need for tx; D/C if ANC <1000; consider D/C if unexplained decr. in WBC; do not cut/crush/chew tab

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[see below]

Child-Pugh Class C: contraindicated