Zenpep

Adult Dosing .

Dosage forms:  DR CAP (lipase/protease/amylase): 3K units/10K units/14K units, 5K units/17K units/24K units, 10K units/32K units/42K units, 15K units/47K units/63K units, 20K units/63K units/84K units, 25K units/79K units/105K units, 40K units/126K units/168K units, 60K units/189.6K units/252.6K units

Special Note

[formulation clarification]

Info: pancrelipase products not interchangeable; retitrate if switching between products

exocrine pancreatic insufficiency

[500-2500 lipase units/kg/dose PO w/ each meal]

Start: 500 lipase units/kg/dose PO w/ each meal; Info: give approx. half of meal dose w/ each snack; adjust dose based on clinical response, steatorrhea, or fat content of diet; may open cap and sprinkle on soft food w/ pH 4.5 or less, but do not crush/chew contents; doses >2500 lipase units/kg/meal, 4000 lipase units/g fat ingested/day, or 10,000 lipase units/kg/day require objective evidence of improved efficacy

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined, caution advised

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  DR CAP (lipase/protease/amylase): 3K units/10K units/14K units, 5K units/17K units/24K units, 10K units/32K units/42K units, 15K units/47K units/63K units, 20K units/63K units/84K units, 25K units/79K units/105K units, 40K units/126K units/168K units, 60K units/189.6K units/252.6K units

Special Note

[formulation clarification]

Info: pancrelipase products not interchangeable; retitrate if switching between products

exocrine pancreatic insufficiency

[<1 yo]

Dose: 3000 lipase units PO per breastfeeding or 4 oz formula; Info: may open cap and sprinkle into infant's mouth or on soft food w/ pH 4.5 or less, but do not crush/chew contents; give before breastfeeding or formula

[1-3 yo]

Dose: 1000-2500 lipase units/kg/dose PO w/ each meal; Start: 1000 lipase units/kg/dose PO w/ each meal; Info: give approx. half of meal dose w/ each snack; adjust dose based on clinical response, steatorrhea, or fat content of diet; may open cap and sprinkle on soft food w/ pH 4.5 or less, but do not crush/chew contents; doses >2500 lipase units/kg/meal, 4000 lipase units/g fat ingested/day, or 10,000 lipase units/kg/day require objective evidence of improved efficacy

[4 yo and older]

Dose: 500-2500 lipase units/kg/dose PO w/ each meal; Start: 500 lipase units/kg/dose PO w/ each meal; Info: give approx. half of meal dose w/ each snack; adjust dose based on clinical response, steatorrhea, or fat content of diet; may open cap and sprinkle on soft food w/ pH 4.5 or less, but do not crush/chew contents; doses >2500 lipase units/kg/meal, 4000 lipase units/g fat ingested/day, or 10,000 lipase units/kg/day require objective evidence of improved efficacy

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined, caution advised

hepatic dosing

[not defined]