Select a medication above to begin.
nortriptyline
generic
Black Box Warnings .
Suicidality
incr. suicidality risk in children, adolescents, and young adults w/ major depressive or other psychiatric disorders; weigh risk vs. benefit; in short-term studies of antidepressants vs. placebo, suicidality risk not incr. in pts >24 yo, and risk decr. in pts 65 yo and older; depression and certain other psychiatric disorders themselves assoc. w/ incr. suicide risk; observe all pts for clinical worsening, suicidality, or unusual behavior changes; advise families and caregivers of need for close observation and communication w/ prescriber; not approved for peds use
Adult Dosing .
Dosage forms: CAP: 10 mg, 25 mg, 50 mg, 75 mg; SOL: 10 mg per 5 mL
depression
- [50-150 mg PO qhs]
- Start: 25-50 mg PO qhs, incr. by 25-50 mg/day q2-3 days; Max: 150 mg/day; Info: may give in divided doses; start 10-25 mg PO qhs in elderly pts, incr. by 10-25 mg/day q2-3 days; taper dose gradually to D/C
IBS (off-label)
- [25-75 mg PO qhs]
- Start: 10 mg PO qhs, titrate slowly; Max: 75 mg/day; Info: taper dose gradually to D/C
cyclic vomiting syndrome prophylaxis, moderate-severe (off-label)
- [75-150 mg PO qhs]
- Start: 25 mg PO qhs, incr. by 10-25 mg/day q2wk; Info: taper dose gradually to D/C
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: CAP: 10 mg, 25 mg, 50 mg, 75 mg; SOL: 10 mg per 5 mL
nocturnal enuresis (off-label)
- [6-7 yo]
- Dose: 10 mg PO qhs; Info: taper dose gradually to D/C
- [8-11 yo]
- Dose: 10-20 mg PO qhs; Info: taper dose gradually to D/C
- [12 yo and older]
- Dose: 25-35 mg PO qhs; Info: taper dose gradually to D/C
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: consider adult renal dosing for guidance
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised