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Black Box Warnings .
Appropriate Use in Peyronie dz tx
restricted distribution program, Xiaflex REMS, due to risk of corporal rupture or other serious penile injury
Serious penile injury in Peyronie dz tx
corporal rupture, severe penile hematoma, sudden penile detumescence, and penile popping sound/sensation reported; promptly evaluate to determine if surgical intervention required
Adult Dosing .
Dosage forms: INJ
Restricted Distribution in US
- [1-877-313-1235 or www.xiaflexrems.com for more info]
- Info: for Peyronie dz tx
Dupuytren contracture
- [0.58 mg intralesionally x1]
- Max: 2 doses/hand at same visit; 3 doses/cord; Info: may repeat q4wk
Peyronie dz
- [0.58 mg intralesionally x2 doses 1-3 days apart]
- Max: 4 cycles; Info: may repeat q6wk
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.