Select a medication above to begin.
Vimovo
naproxen/ esomeprazole
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, incl. MI and stroke; risk may occur early in tx and may incr. w/ duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events incl. bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and w/o warning sx; elderly pts and pts w/ hx of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: DR TAB: 375 mg/20 mg, 500 mg/20 mg
osteoarthritis
- [375 mg/20 mg or 500 mg/20 mg PO bid]
- Info: for pts w/ NSAID-assoc. gastric ulcer risk; use lowest effective dose, shortest effective tx duration; do not cut/crush/chew tab; give 30min before meals
rheumatoid arthritis
- [375 mg/20 mg or 500 mg/20 mg PO bid]
- Info: for pts w/ NSAID-assoc. gastric ulcer risk; use lowest effective dose, shortest effective tx duration; do not cut/crush/chew tab; give 30min before meals
ankylosing spondylitis
- [375 mg/20 mg or 500 mg/20 mg PO bid]
- Info: for pts w/ NSAID-assoc. gastric ulcer risk; use lowest effective dose, shortest effective tx duration; do not cut/crush/chew tab; give 30min before meals
renal dosing
- [see below]
- CrCl >60: no adjustment; CrCl 30-60: not defined, caution advised; CrCl <30: avoid use; advanced renal dz: avoid use
- HD/PD: avoid use
hepatic dosing
- [see below]
- Child-Pugh Class A or B: avoid use, dose adjustment not possible w/ fixed-dose combo; Child-Pugh Class C: avoid use
Peds Dosing .
- Dosage forms: DR TAB: 375 mg/20 mg, 500 mg/20 mg
juvenile idiopathic arthritis
- [12 yo and older, 38-50 kg]
- Dose: 375 mg/20 mg PO bid; Info: for pts w/ NSAID-assoc. gastric ulcer risk; use lowest effective dose, shortest effective tx duration; do not cut/crush/chew tab; give 30min before meals
- [12 yo and older, >50 kg]
- Dose: 375 mg/20 mg or 500 mg/20 mg PO bid; Info: for pts w/ NSAID-assoc. gastric ulcer risk; use lowest effective dose, shortest effective tx duration; do not cut/crush/chew tab; give 30min before meals
renal dosing
- [see below]
- CrCl >60: no adjustment; CrCl 30-60: not defined, caution advised; CrCl <30: avoid use; advanced renal dz: avoid use
- HD/PD: avoid use
hepatic dosing
- [see below]
- Child-Pugh Class A or B: avoid use, dose adjustment not possible w/ fixed-dose combo; Child-Pugh Class C: avoid use