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Black Box Warnings .
Fetal Toxicity
fetal/neonatal morbidity/mortality may occur when drugs that act directly on the renin-angiotensin system are used in pregnancy; D/C drug ASAP once pregnancy detected
Adult Dosing .
Dosage forms: TAB: 20 mg/5 mg/12.5 mg, 40 mg/5 mg/12.5 mg, 40 mg/5 mg/25 mg, 40 mg/10 mg/12.5 mg, 40 mg/10 mg/25 mg
HTN
- [1 tab PO qd]
- Max: 40 mg/10 mg/25 mg/day; Info: not for initial tx; may incr. dose after 2wk
renal dosing
- [see below]
- CrCl >20: no adjustment; CrCl 10-20: not defined, caution advised; CrCl <10: avoid use; anuria: contraindicated
- HD/PD: avoid use
hepatic dosing
- [see below]
- hepatic impairment: avoid use as initial tx, lower amlodipine dose not possible w/ fixed-dose combo
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.