Tirosint

Adult Dosing .

Dosage forms:  CAP: 13 mcg, 25 mcg, 37.5 mcg, 44 mcg, 50 mcg, 62.5 mcg, 75 mcg, 88 mcg, 100 mcg, 112 mcg, 125 mcg, 137 mcg, 150 mcg, 175 mcg, 200 mcg; SOL: 13 mcg per mL, 25 mcg per mL, 37.5 mcg per mL, 44 mcg per mL, 50 mcg per mL, 62.5 mcg per mL, 75 mcg per mL, 88 mcg per mL, 100 mcg per mL, 112 mcg per mL, 125 mcg per mL, 137 mcg per mL, 150 mcg per mL, 175 mcg per mL, 200 mcg per mL

Special Note

[thyroid product equivalencies]

Info: for product conversion purposes, 100 mcg levothyroxine = 25 mcg liothyronine = 60-65 mg thyroid (porcine) = 1 grain liotrix

hypothyroidism

[50-200 mcg PO qd]

Start: 1.6 mcg/kg/dose PO qd, then adjust dose by 12.5-25 mcg/day q4-6wk; Info: adjust dose based on TFTs; doses >300 mcg/day rarely needed; use lower start dose, then adjust dose q6-8wk in elderly pts and pts w/ cardiac dz; dose adjustments may be needed during pregnancy and/or immed. postpartum; give cap on empty stomach, 30-60min before breakfast; give solution on empty stomach, 15min before breakfast

TSH suppression

[individualize dose PO qd]

Info: for pts w/ thyrotropin-dependent well-differentiated thyroid CA; adjust dose to suppress TSH to levels based on clinical status; dose adjustments may be needed during pregnancy and/or immed. postpartum; give cap on empty stomach, 30-60min before breakfast; give solution on empty stomach, 15min before breakfast

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  CAP: 13 mcg, 25 mcg, 37.5 mcg, 44 mcg, 50 mcg, 62.5 mcg, 75 mcg, 88 mcg, 100 mcg, 112 mcg, 125 mcg, 137 mcg, 150 mcg, 175 mcg, 200 mcg; SOL: 13 mcg per mL, 25 mcg per mL, 37.5 mcg per mL, 44 mcg per mL, 50 mcg per mL, 62.5 mcg per mL, 75 mcg per mL, 88 mcg per mL, 100 mcg per mL, 112 mcg per mL, 125 mcg per mL, 137 mcg per mL, 150 mcg per mL, 175 mcg per mL, 200 mcg per mL

Special Note

[thyroid product equivalencies]

Info: for product conversion purposes, 100 mcg levothyroxine = 25 mcg liothyronine = 60-65 mg thyroid (porcine) = 1 grain liotrix

hypothyroidism

[<3 mo]

Dose: individualize dose PO qd; Start: 10-15 mcg/kg/dose PO qd, then adjust dose q2wk; Info: adjust dose based on TFTs; use lower start dose and incr. dose q4-6wk if risk for cardiac failure; give solution on empty stomach, 15min before morning meal

[3-5 mo]

Dose: individualize dose PO qd; Start: 8-10 mcg/kg/dose PO qd, then adjust dose q2wk; Info: adjust dose based on TFTs; give solution on empty stomach, 15min before morning meal

[6-11 mo]

Dose: individualize dose PO qd; Start: 6-8 mcg/kg/dose PO qd, then adjust dose q2wk; Info: adjust dose based on TFTs; give solution on empty stomach, 15min before morning meal

[1-5 yo]

Dose: individualize dose PO qd; Start: 5-6 mcg/kg/dose PO qd, then adjust dose q2wk; Info: adjust dose based on TFTs; start 25% usual start dose, then incr. by 25% usual start dose qwk if hyperactivity risk; give solution on empty stomach, 15min before breakfast

[6-12 yo]

Dose: individualize dose PO qd; Start: 4-5 mcg/kg/dose PO qd, then adjust dose q2wk; Info: adjust dose based on TFTs; start 25% usual start dose, then incr. by 25% usual start dose qwk if hyperactivity risk; give cap on empty stomach, 30-60min before breakfast; give solution on empty stomach, 15min before breakfast

[>12 yo, growth/puberty incomplete]

Dose: individualize dose PO qd; Start: 2-3 mcg/kg/dose PO qd, then adjust dose q2wk; Info: adjust dose based on TFTs; start 25% usual start dose, then incr. by 25% usual start dose qwk if hyperactivity risk; give cap on empty stomach, 30-60min before breakfast; give solution on empty stomach, 15min before breakfast

[>12 yo, growth/puberty complete]

Dose: 50-200 mcg PO qd; Start: 1.6 mcg/kg/dose PO qd, then adjust dose by 12.5-25 mcg/day q4-6wk; Info: adjust dose based on TFTs; doses >300 mcg/day rarely needed; use lower start dose, then adjust dose q6-8wk in pts w/ cardiac dz; start 25% usual start dose, then incr. by 25% usual start dose qwk if hyperactivity risk; dose adjustments may be needed during pregnancy and/or immed. postpartum; give cap on empty stomach, 30-60min before breakfast; give solution on empty stomach, 15min before breakfast

TSH suppression

[individualize dose PO qd]

Info: for pts w/ thyrotropin-dependent well-differentiated thyroid CA; adjust dose to suppress TSH to levels based on clinical status; dose adjustments may be needed during pregnancy and/or immed. postpartum; give cap on empty stomach, 30-60min before breakfast; give solution on empty stomach, 15min before breakfast

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]