Teflaro

Adult Dosing .

Dosage forms:  INJ

pneumonia, community-acquired

[600 mg IV q12h for at least 5 days]

Info: for inpatient tx; part of multi-drug regimen; refer to IDSA guidelines

skin/skin structure infections, acute bacterial

[600 mg IV q12h x5-14 days]

renal dosing

[adjust dose amount]

CrCl 31-50: 400 mg q12h; CrCl 15-30: 300 mg q12h; CrCl <15: 200 mg q12h

HD: 200 mg q12h, on dialysis days admin. after dialysis; supplement not defined; PD: not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  INJ

pneumonia, community-acquired

[2-23 mo]

Dose: 8 mg/kg/dose IV q8h x5-14 days

[2 yo and older, <33 kg]

Dose: 12 mg/kg/dose IV q8h x5-14 days

[2 yo and older, >33 kg]

Dose: 400 mg IV q8h x5-14 days; Alt: 600 mg IV q12h x5-14 days

skin/skin structure infections, acute bacterial

[<2 mo]

Dose: 6 mg/kg/dose IV q8h x5-14 days; Info: for pts >34 wk gestation, >12 days old

[2-23 mo]

Dose: 8 mg/kg/dose IV q8h x5-14 days

[2 yo and older, <33 kg]

Dose: 12 mg/kg/dose IV q8h x5-14 days

[2 yo and older, >33 kg]

Dose: 400 mg IV q8h x5-14 days; Alt: 600 mg IV q12h x5-14 days

bacterial arthritis, acute (off-label)

[45 mg/kg/day IV divided q8h]

Info: duration varies by infection severity

renal dosing

[see below]

CrCl 31-50: give 66% usual divided dose q8-12h; CrCl 15-30: give 50% usual divided dose q8-12h; CrCl <15: give 33% usual divided dose q8-12h

HD: give 33% usual divided dose q12h, on dialysis days admin. after dialysis; supplement not defined; PD: not defined

hepatic dosing

[no adjustment]