Select a medication above to begin.
lurasidone
generic
Black Box Warnings .
Dementia-Related Psychosis
not approved for dementia-related psychosis; incr. mortality risk in elderly dementia pts on conventional or atypical antipsychotics; most deaths due to cardiovascular or infectious events; extent to which incr. mortality attributed to antipsychotic vs. some pt characteristic(s) not clear
Suicidality
incr. suicidality risk in children, adolescents, and young adults w/ major depressive or other psychiatric disorders; weigh risk vs. benefit; in short-term studies of antidepressants vs. placebo, suicidality risk not incr. in pts >24 yo, and risk decr. in pts 65 yo and older; depression and certain other psychiatric disorders themselves assoc. w/ incr. suicide risk; observe all pts for clinical worsening, suicidality, or unusual behavior changes; advise families and caregivers of need for close observation and communication w/ prescriber
Adult Dosing .
Dosage forms: TAB: 20 mg, 40 mg, 60 mg, 80 mg, 120 mg
schizophrenia
- [40-160 mg PO qd]
- Start: 40 mg PO qd; Max: 160 mg/day; Info: give w/ food containing >350 calories
bipolar I disorder, acute depressive
- [20-120 mg PO qd]
- Start: 20 mg PO qd; Max: 120 mg/day; Info: for monotherapy or valproate or lithium adjunct; doses >80 mg/day rarely more effective as monotherapy; give w/ food containing >350 calories
renal dosing
- [see below]
- CrCl <50: start 20 mg qd, max 80 mg/day
- HD/PD: not defined
hepatic dosing
- [adjust dose amount]
- Child-Pugh Class B: start 20 mg qd, max 80 mg/day; Class-Pugh Class C: start 20 mg qd, max 40 mg/day
Peds Dosing .
- Dosage forms: TAB: 20 mg, 40 mg, 60 mg, 80 mg
schizophrenia
- [13-17 yo]
- Dose: 40-80 mg PO qd; Start: 40 mg PO qd; Max: 80 mg/day; Info: give w/ food containing >350 calories
bipolar I disorder, acute depressive
- [10-17 yo]
- Dose: 20-80 mg PO qd; Start: 20 mg PO qd x1wk; Max: 80 mg/day; Info: for monotherapy; give w/ food containing >350 calories
renal dosing
- [see below]
- CrCl <50: start 20 mg qd, max 80 mg/day
- HD/PD: not defined
hepatic dosing
- [adjust dose amount]
- Child-Pugh Class B: start 20 mg qd, max 80 mg/day; Class-Pugh Class C: start 20 mg qd, max 40 mg/day