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ketorolac nasal
generic
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, incl. MI and stroke; risk may occur early in tx and may incr. w/ duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events incl. bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and w/o warning sx; elderly pts and pts w/ hx of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: SPRAY: 15.75 mg per actuation
pain, moderate-mod. severe
- [<65 yo, <50 kg]
- Dose: 1 actuation in one nostril q6-8h; Max: 4 actuations/day; Info: combined duration of any ketorolac tx not to exceed 5 days; use lowest effective dose, shortest effective tx duration
- [<65 yo, >50 kg]
- Dose: 1 actuation in each nostril q6-8h; Max: 8 actuations/day; Info: combined duration of any ketorolac tx not to exceed 5 days; use lowest effective dose, shortest effective tx duration
- [65 yo and older]
- Dose: 1 actuation in one nostril q6-8h; Max: 4 actuations/day; Info: combined duration of any ketorolac tx not to exceed 5 days; use lowest effective dose, shortest effective tx duration
renal dosing
- [see below]
- renal impairment: 1 actuation in one nostril q6-8h, max 4 actuations/day; advanced renal dz: contraindicated
- HD/PD: contraindicated
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.