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ibuprofen/ famotidine
generic
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, incl. MI and stroke; risk may occur early in tx and may incr. w/ duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events incl. bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and w/o warning sx; elderly pts and pts w/ hx of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: TAB: 800 mg/26.6 mg
Special Note
- [formulation clarification]
- Info: not interchangeable w/ single-ingredient ibuprofen and/or famotidine products
osteoarthritis
- [1 tab PO tid]
- Info: for pts requiring upper GI ulcer risk reduction; use shortest effective tx duration; give w/ food if GI upset occurs; do not cut/crush/chew tab
rheumatoid arthritis
- [1 tab PO tid]
- Info: for pts requiring upper GI ulcer risk reduction; use shortest effective tx duration; give w/ food if GI upset occurs; do not cut/crush/chew tab
renal dosing
- [see below]
- CrCl >60: no adjustment; CrCl 50-60: not defined, caution advised; CrCl <50: avoid use, dose adjustment not possible w/ fixed-dose combo
- HD/PD: avoid use
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.