Inlyta

Adult Dosing .

Dosage forms:  TAB: 1 mg, 5 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments; D/C >2 days before elective surgery, restart >14 days after major surgery when wound fully healed

renal cell CA, advanced

[first-line tx, combo w/ avelumab]

Dose: 5-10 mg PO q12h; Start: 5 mg PO q12h for at least 2wk, if normotensive w/o receiving antihypertensive, and no Grade >2 ADR, may incr. to 7 mg PO q12h, then 10 mg PO q12h no more frequently than q2wk; Info: do not cut/crush/chew tab

[first-line tx, combo w/ pembrolizumab]

Dose: 5-10 mg PO q12h; Start: 5 mg PO q12h for at least 6wk, if normotensive w/o receiving antihypertensive, and no Grade >2 ADR, may incr. to 7 mg PO q12h, then 10 mg PO q12h no more frequently than q6wk; Info: do not cut/crush/chew tab

[2nd-line tx, monotherapy]

Dose: 5-10 mg PO q12h; Start: 5 mg PO q12h for at least 2wk, if normotensive w/o receiving antihypertensive, and no Grade >2 ADR, may incr. to 7 mg PO q12h, then 10 mg PO q12h no more frequently than q2wk; Info: do not cut/crush/chew tab

renal dosing

[see below]

CrCl >15: no adjustment; CrCl <15: not defined, caution advised

HD/PD: not defined

hepatic dosing

[adjust dose amount]

Child-Pugh Class B: decr. usual start dose by approx. 50%; Child-Pugh Class C: not defined

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.