Exparel

Adult Dosing .

Dosage forms:  INJ (1.3%): 133 mg per 10 mL, 266 mg per 20 mL

Special Note

[formulation clarification]

Info: not interchangeable w/ bupivacaine; do not substitute on a mg to mg basis

local analgesia, postop

[infiltration]

Dose: up to 266 mg via infiltration x1; Max: 266 mg/dose; Info: see pkg insert for bunionectomy and hemorrhoidectomy dosing examples

regional analgesia, postop

[interscalene brachial plexis nerve block]

Dose: 133 mg perineurally x1; Max: 133 mg/dose

[sciatic nerve block]

Dose: 133 mg perineurally x1; Max: 133 mg/dose; Info: for use in popliteal fossa

[adductor canal block]

Dose: 133 mg perineurally x1; Max: 133 mg/dose; Info: admix dose w/ 50 mg of 0.5% bupivacaine

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  INJ (1.3%): 133 mg per 10 mL, 266 mg per 20 mL

Special Note

[formulation clarification]

Info: not interchangeable w/ bupivacaine; do not substitute on a mg to mg basis

local analgesia, postop

[infiltration, 6-17 yo]

Dose: 4 mg/kg/dose via infiltration x1; Max: 266 mg/dose

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised