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Korlym
mifepristone
Black Box Warnings .
Termination of Pregnancy
potent antagonist of progesterone and cortisol via progesterone and glucocorticoid receptors, respectively; antiprogestational effects result in pregnancy termination; exclude pregnancy prior to tx start and if tx interrupted >14 days in female pts of reproductive potential; avoid pregnancy during tx and x1mo after D/C by using non-hormonal contraception, unless surgical sterilization hx
Adult Dosing .
Dosage forms: TAB: 300 mg
Restricted Distribution in US
- [1-855-456-7956 or www.korlym.com for more info]
hyperglycemia, Cushing syndrome-associated
- [300-1200 mg PO qd]
- Start: 300 mg PO qd, may incr. dose by 300 mg/day no more frequently than q2-4wk; Max: 20 mg/kg/day up to 1200 mg/day; Info: for pts w/ type 2 diabetes mellitus or glucose intolerance; use lowest effective dose; retitrate from 300 mg PO qd if tx interrupted; give w/ meals; do not cut/crush/chew tab
renal dosing
- [adjust dose amount]
- renal impairment: max 600 mg/day
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class A or B: max 600 mg/day; Child-Pugh Class C: avoid use
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.