Diovan

Adult Dosing .

Dosage forms:  TAB: 40 mg, 80 mg, 160 mg, 320 mg

Special Note

[formulation clarification]

Info: valsartan exposure 1.6x greater for extemporaneously prepared susp vs. tabs; monitor closely and consider dose adjustment if switching between forms

HTN

[80-320 mg PO qd]

Start: 80-160 mg PO qd; Max: 320 mg/day; Info: consider lower start dose if volume depletion; see pkg insert for suspension preparation

heart failure w/ reduced ejection fraction, NYHA Class II-IV

[160 mg PO bid]

Start: 40 mg PO bid; Max: 320 mg/day; Info: see pkg insert for suspension preparation

left ventricular dysfxn, post-MI

[160 mg PO bid]

Start: 20 mg PO bid >12h post-MI, then may incr. to 40 mg PO bid w/in 7 days, then may incr. to 160 mg PO bid as tolerated; Max: 320 mg/day; Info: see pkg insert for suspension preparation

renal dosing

[see below]

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

hepatic dosing

[see below]

mild-moderate impairment: no adjustment; severe impairment: not defined

Peds Dosing .

Dosage forms:  TAB: 40 mg, 80 mg, 160 mg, 320 mg

Special Note

[formulation clarification]

Info: valsartan exposure 1.6x greater for extemporaneously prepared susp vs. tabs; monitor closely and consider dose adjustment if switching between forms

HTN

[1-16 yo]

Dose: 1-4 mg/kg/dose PO qd; Start: 1 mg/kg/dose up to 40 mg PO qd; Max: 4 mg/kg/day up to 160 mg/day; Info: may start 2 mg/kg/dose PO qd if greater BP decr. needed; consider lower start dose if volume depletion; see pkg insert for suspension preparation

[17 yo and older]

Dose: 80-320 mg PO qd; Start: 80-160 mg PO qd; Max: 320 mg/day; Info: consider lower start dose if volume depletion; see pkg insert for suspension preparation

renal dosing

[see below]

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

hepatic dosing

[see below]

mild-moderate impairment: no adjustment; severe impairment: not defined