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valsartan/ hydrochlorothiazide
generic
Black Box Warnings .
Fetal Toxicity
fetal/neonatal morbidity/mortality may occur when drugs that act directly on the renin-angiotensin system are used in pregnancy; D/C drug ASAP once pregnancy detected
Adult Dosing .
Dosage forms: TAB: 80 mg/12.5 mg, 160 mg/12.5 mg, 160 mg/25 mg, 320 mg/12.5 mg, 320 mg/25 mg
HTN
- [initial therapy]
- Dose: 1 tab PO qd; Start: 160 mg/12.5 mg PO qd, may incr. dose after 1-2wk; Max: 320 mg/25 mg/day; Info: for use as initial tx if BP control unlikely on single agent
- [replacement/add-on therapy]
- Dose: 1 tab PO qd; Start: same doses of both components if replacement tx; start combo at lower dose of either valsartan or HCTZ if receiving prior max tolerable dose of that component as monotherapy; may incr. dose after 3-4wk; Max: 320 mg/25 mg/day
renal dosing
- [see below]
- CrCl > 30: no adjustment; CrCl 10-30: not defined, caution advised; CrCl <10: avoid use; anuria: contraindicated
- HD/PD: avoid use
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.