acetaminophen rectal

Adult Dosing .

Dosage forms:  SUPP: 325 mg, 650 mg

pain, mild

[325-650 mg PR q4-6h prn]

Max: 6 doses/day; 4 g/day from all sources

fever

[325-650 mg PR q4-6h prn]

Max: 6 doses/day; 4 g/day from all sources

renal dosing

[adjust dose frequency]

CrCl 10-50: give usual dose q6h prn; CrCl <10: give usual dose q8h prn

HD: give usual dose q8h prn; no supplement after dialysis; PD: give usual dose q8h prn; no supplement

hepatic dosing

[see below]

hepatic impairment: consider decr. usual dose

Peds Dosing .

Dosage forms:  SUPP: 80 mg, 120 mg, 325 mg, 650 mg

pain, mild

[neonates]

Dose: 10-15 mg/kg/dose PR q6-8h prn; Max: 4 doses/day; 60 mg/kg/day from all sources

[infants/children]

Dose: 10-15 mg/kg/dose PR q4-6h prn; Max: 5 doses/day; 75 mg/kg/day up to 4 g/day from all sources

[adolescents]

Dose: 325-650 mg PR q4-6h prn; Max: 6 doses/day; 4 g/day from all sources

fever

[neonates]

Dose: 10-15 mg/kg/dose PR q6-8h prn; Max: 4 doses/day; 60 mg/kg/day from all sources

[infants/children]

Dose: 10-15 mg/kg/dose PR q4-6h prn; Max: 5 doses/day; 75 mg/kg/day up to 4 g/day from all sources

[adolescents]

Dose: 325-650 mg PR q4-6h prn; Max: 6 doses/day; 4 g/day from all sources

renal dosing

[adjust dose frequency]

CrCl 10-50: give usual dose q6-8h prn; CrCl <10: give usual dose q8h prn

HD: give usual dose q8h prn; no supplement after dialysis; PD: give usual dose q8h prn; no supplement

hepatic dosing

[see below]

hepatic impairment: consider decr. usual dose