prednisolone

Adult Dosing .

Dosage forms:  TAB: 5 mg; ODT: 10 mg, 15 mg, 30 mg; SOL: 5 mg per 5 mL, 10 mg per 5 mL, 15 mg per 5 mL, 20 mg per 5 mL, 25 mg per 5 mL

corticosteroid-responsive conditions

[5-60 mg/day PO divided qd-qid]

Info: dose, frequency varies by condition; give w/ food; do not cut/crush/chew ODT form; taper dose gradually to D/C if high-dose or long-term use

asthma, acute

[ED/hospital management]

Dose: 40-80 mg/day PO divided qd-bid; Info: cont. until peak flow 70% predicted; give w/ food; do not cut/crush/chew ODT form

[outpatient burst tx]

Dose: 40-60 mg/day PO divided qd-bid x3-10 days; Info: give w/ food; do not cut/crush/chew ODT form

asthma, severe persistent

[7.5-60 mg PO qd-qod]

Info: give w/ food; do not cut/crush/chew ODT form; taper dose gradually to D/C if high-dose or long-term use

adrenal insufficiency

[4-5 mg/m^2/dose PO qd]

Info: give w/ food; do not cut/crush/chew ODT form; taper dose gradually to D/C

multiple sclerosis, acute exacerbation

[1250 mg PO qd x3-5 days]

Info: give w/ food; do not cut/crush/chew ODT form

gout, acute

[0.5 mg/kg/day PO x5-10 days]

Info: give w/ food; do not cut/crush/chew ODT form

alcoholic hepatitis, acute (off-label)

[40 mg PO qd]

Info: give w/ food; do not cut/crush/chew ODT form; taper dose gradually to D/C

minimal change dz (off-label)

[1 mg/kg/dose PO qd x4-16wk]

Max: 80 mg/day; Alt: 2 mg/kg/dose PO qod x4-16wk, max 120 mg/dose; Info: give w/ food; do not cut/crush/chew ODT form; taper dose gradually to D/C over at least 24wk; refer to KDIGO guidelines

focal segmental glomerulosclerosis, primary (off-label)

[1 mg/kg/dose PO qd x4-16wk, then taper dose by 5 mg/day q1-2wk to complete 6mo total]

Max: 80 mg/day; Alt: 2 mg/kg/dose PO qod x4-16wk, then taper dose by 5 mg/day q1-2wk to complete 6mo total, max 120 mg/dose; Info: give w/ food; do not cut/crush/chew ODT form; refer to KDIGO guidelines

Duchenne muscular dystrophy (off-label)

[0.75 mg/kg/dose PO qd]

Max: 40 mg/day; Info: give w/ food; do not cut/crush/chew ODT form; may taper dose to 0.3 mg/kg/dose PO qd if not tolerated; doses >0.75 mg/kg/day rarely more effective, may incr. ADR risk; taper dose gradually to D/C

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  TAB: 5 mg; ODT: 10 mg, 15 mg, 30 mg; SOL: 5 mg per 5 mL, 10 mg per 5 mL, 15 mg per 5 mL, 20 mg per 5 mL, 25 mg per 5 mL

corticosteroid-responsive conditions

[0.14-2 mg/kg/day PO divided qd-qid]

Alt: 4-60 mg/m^2/day PO divided qd-qid; Info: dose, frequency varies by condition; give w/ food; do not cut/crush/chew ODT form; taper dose gradually to D/C if high-dose or long-term use

asthma, acute

[ED/hospital management]

Dose: 1-2 mg/kg/day PO divided qd-bid; Max: 60 mg/day; Info: cont. until peak flow 70% predicted; give w/ food; do not cut/crush/chew ODT form

[outpatient burst tx]

Dose: 1-2 mg/kg/day PO divided qd-bid x3-10 days; Max: 60 mg/day; Info: give w/ food; do not cut/crush/chew ODT form

asthma, severe persistent

[0.25-2 mg/kg/dose PO qd-qod]

Max: 60 mg/day; Info: give w/ food; do not cut/crush/chew ODT form; taper dose gradually to D/C if high-dose or long-term use

adrenal insufficiency

[4-5 mg/m^2/dose PO qd]

Info: give w/ food; do not cut/crush/chew ODT form; taper dose gradually to D/C

nephrotic syndrome

[60 mg/m^2/day PO divided qd-tid x4-6wk, then 40 mg/m^2/dose PO qod x4-6wk]

Max: 60 mg/day if qd-tid dosing; 50 mg/dose if qod dosing; Alt: 2 mg/kg/day PO divided qd-tid x4-6wk, then 1.5 mg/kg/dose PO qod x4-6wk; Info: give w/ food; do not cut/crush/chew ODT form; refer to KDIGO guidelines

Duchenne muscular dystrophy (off-label)

[0.75 mg/kg/dose PO qd]

Max: 40 mg/day; Info: give w/ food; do not cut/crush/chew ODT form; may taper dose to 0.3 mg/kg/dose PO qd if not tolerated; doses >0.75 mg/kg/day rarely more effective, may incr. ADR risk; taper dose gradually to D/C

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[not defined]