Diuril

Adult Dosing .

Dosage forms:  SUSP: 250 mg per 5 mL

Dosage Forms Discontinued in US

[IV not avail. as brand; see generic]

edema, adjunct tx

[500-1000 mg PO/IV qd-bid]

Info: for pts on corticosteroid or estrogen tx or w/ CHF, renal dz or hepatic dz; maint. doses may be given intermittently

HTN

[500-1000 mg/day PO divided qd-bid]

Max: 2000 mg/day

renal dosing

[see below]

CrCl <10: avoid use; anuria: contraindicated; Info: caution advised if severe impairment

HD: not defined; PD: avoid use

hepatic dosing

[see below]

hepatic impairment/progressive hepatic dz: not defined, caution advised

Peds Dosing .

Dosage forms:  SUSP: 250 mg per 5 mL

edema, adjunct tx

[<6 mo]

Dose: 10-30 mg/kg/day PO divided q12h; Max: 375 mg/day

[6 mo-12 yo]

Dose: 10-20 mg/kg/day PO divided q12-24h; Max: 375 mg/day (<2 yo), 1 g/day (2-12 yo)

HTN

[<6 mo]

Dose: 10-30 mg/kg/day PO divided q12h; Max: 375 mg/day

[6 mo-12 yo]

Dose: 10-20 mg/kg/day PO divided q12-24h; Max: 375 mg/day (<2 yo), 1 g/day (2-12 yo)

renal dosing

[see below]

CrCl <10: avoid use; anuria: contraindicated; Info: caution advised if severe impairment

HD/PD: avoid use

hepatic dosing

[see below]

hepatic impairment/progressive hepatic dz: not defined, caution advised