primaquine phosphate

Adult Dosing .

Dosage forms:  TAB: 26.3 mg

Special Note

[strength clarification]

Info: 26.3 mg primaquine phosphate = 15 mg primaquine base; doses expressed as primaquine phosphate

malaria antirelapse tx

[52.6 mg PO qd x14 days]

Info: give after uncomplicated malaria tx for P. vivax or P. ovale; in pts >70 kg, give 10.5 mg/kg per tx course divided into 52.6 mg daily doses, max 52.6 mg/day; if intermediate G6PD deficiency, may give 78.9 mg PO qwk x8wk; refer to CDC guidelines

malaria prophylaxis, primary (off-label)

[52.6 mg PO qd]

Start: 1-2 days before exposure; Info: for short duration travel to areas w/ primarily P. vivax; D/C 7 days after exposure; see CDC Pre-Travel Malaria Prophylaxis recommendations in Guidelines > Specialties > Infectious Diseases

malaria prophylaxis, terminal (off-label)

[52.6 mg PO qd x14 days]

Start: after leaving malarious area; Info: for presumptive antirelapse tx (PART) to prevent relapses or delayed-onset P. vivax and P. ovale malaria after prolonged exposure; refer to CDC Yellow Book

PCP (off-label)

[52.6 mg PO qd]

Info: not 1st-line agent; give w/ clindamycin

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  TAB: 26.3 mg

Special Note

[strength clarification]

Info: 26.3 mg primaquine phosphate = 15 mg primaquine base; doses expressed as primaquine phosphate

malaria antirelapse tx (off-label)

[0.8 mg/kg/dose PO qd x14 days]

Max: 52.6 mg/day; Info: give after uncomplicated malaria tx for P. vivax or P. ovale; in pts >70 kg, give 10.5 mg/kg per tx course divided into 52.6 mg daily doses, max 52.6 mg/day; if intermediate G6PD deficiency, may give 1.2 mg/kg/dose PO qwk x8wk, max 78.9 mg/dose; refer to CDC guidelines

malaria prophylaxis, primary (off-label)

[0.8 mg/kg/dose PO qd]

Start: 1-2 days before exposure; Max: 52.6 mg/day; Info: for short duration travel to areas w/ primarily P. vivax; D/C 7 days after exposure; see CDC Pre-Travel Malaria Prophylaxis recommendations in Guidelines > Specialties > Infectious Diseases

malaria prophylaxis, terminal (off-label)

[0.8 mg/kg/dose PO qd x14 days]

Start: after leaving malarious area; Max: 52.6 mg/day; Info: for presumptive antirelapse tx (PART) to prevent relapses or delayed-onset P. vivax and P. ovale malaria after prolonged exposure; refer to CDC Yellow Book

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

hepatic dosing

[not defined]