Buphenyl

Adult Dosing .

Dosage forms:  TAB: 500 mg; PWDR: 3 g per tsp, 8.6 g per Tbsp

chronic hyperammonemia, urea cycle disorder-assoc.

[9.9-13 g/m^2/day PO divided 3-6x/day]

Max: 20 g/day; Info: for pts w/ carbamylphosphate synthetase, ornithine transcarbamylase, or argininosuccinic acid synthetase deficiency; adjust dose based on pt clinical response and plasma ammonia levels; give w/ food; separate doses by at least 3h

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined, caution advised

hepatic dosing

[adjust dose amount]

hepatic impairment: use lowest usual start dose

Peds Dosing .

Dosage forms:  TAB: 500 mg; PWDR: 3 g per tsp, 8.6 g per Tbsp

chronic hyperammonemia, urea cycle disorder-assoc.

[<20 kg]

Dose: 450-600 mg/kg/day PO divided 3-6x/day; Max: 20 g/day; Info: for pts w/ carbamylphosphate synthetase, ornithine transcarbamylase, or argininosuccinic acid synthetase deficiency; adjust dose based on pt clinical response and plasma ammonia levels; give w/ food; separate doses by at least 3h

[>20 kg]

Dose: 9.9-13 g/m^2/day PO divided 3-6x/day; Max: 20 g/day; Info: for pts w/ carbamylphosphate synthetase, ornithine transcarbamylase, or argininosuccinic acid synthetase deficiency; adjust dose based on pt clinical response and plasma ammonia levels; give w/ food; separate doses by at least 3h

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined, caution advised

hepatic dosing

[adjust dose amount]

hepatic impairment: use lowest usual start dose