Mekinist

Adult Dosing .

Dosage forms:  TAB: 0.5 mg, 2 mg; SOL: 0.05 mg per mL

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

BRAF V600E- or V600K-positive melanoma

[adjuvant tx]

Dose: 2 mg PO qd for up to 1y; Info: use w/ dabrafenib; give at least 1h before or 2h after meals; do not cut/crush/chew tab

[unresectable or metastatic dz]

Dose: 2 mg PO qd; Info: use as monotherapy or w/ dabrafenib; give at least 1h before or 2h after meals; do not cut/crush/chew tab

BRAF V600E-positive non-small cell lung CA, metastatic

[2 mg PO qd]

Info: use w/ dabrafenib; give at least 1h before or 2h after meals; do not cut/crush/chew tab

BRAF V600E-positive anaplastic thyroid CA, locally advanced or metastatic

[2 mg PO qd]

Info: use w/ dabrafenib; give at least 1h before or 2h after meals; do not cut/crush/chew tab

BRAF V600E-positive solid tumors, unresectable or metastatic

[2 mg PO qd]

Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ dabrafenib; give at least 1h before or 2h after meals; do not cut/crush/chew tab

BRAF V600E-positive glioma, low-grade

[2 mg PO qd]

Info: use w/ dabrafenib; give at least 1h before or 2h after meals; do not cut/crush/chew tab

renal dosing

[see below]

eGFR >15: no adjustment; eGFR <15: not defined

HD/PD: not defined

hepatic dosing

[see below]

bilirubin 1.1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN: not defined

Peds Dosing .

Dosage forms:  TAB: 0.5 mg, 2 mg; SOL: 0.05 mg per mL

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

BRAF V600E-positive solid tumors, unresectable or metastatic

[tab form, 1 yo and older, 26-37 kg]

Dose: 1 mg PO qd; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ dabrafenib; give at least 1h before or 2h after meals; do not cut/crush/chew tab

[tab form, 1 yo and older, 38-50 kg]

Dose: 1.5 mg PO qd; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ dabrafenib; give at least 1h before or 2h after meals; do not cut/crush/chew tab

[tab form, 1 yo and older, >51 kg]

Dose: 2 mg PO qd; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ dabrafenib; give at least 1h before or 2h after meals; do not cut/crush/chew tab

[solution form, 1 yo and older, 8 kg]

Dose: 0.3 mg PO qd; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, 9-10 kg]

Dose: 0.35 mg PO qd; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, 11 kg]

Dose: 0.4 mg PO qd; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, 12-13 kg]

Dose: 0.45 mg PO qd; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, 14-17 kg]

Dose: 0.55 mg PO qd; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, 18-21 kg]

Dose: 0.7 mg PO qd; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, 22-25 kg]

Dose: 0.85 mg PO qd; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, 26-29 kg]

Dose: 0.9 mg PO qd; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, 30-33 kg]

Dose: 1 mg PO qd; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, 34-37 kg]

Dose: 1.15 mg PO qd; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, 38-41 kg]

Dose: 1.25 mg PO qd; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, 42-45 kg]

Dose: 1.4 mg PO qd; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, 46-50 kg]

Dose: 1.6 mg PO qd; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, >51 kg]

Dose: 2 mg PO qd; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ dabrafenib; give at least 1h before or 2h after meals

BRAF V600E-positive glioma, low-grade

[tab form, 1 yo and older, 26-37 kg]

Dose: 1 mg PO qd; Info: use w/ dabrafenib; give at least 1h before or 2h after meals; do not cut/crush/chew tab

[tab form, 1 yo and older, 38-50 kg]

Dose: 1.5 mg PO qd; Info: use w/ dabrafenib; give at least 1h before or 2h after meals; do not cut/crush/chew tab

[tab form, 1 yo and older, >51 kg]

Dose: 2 mg PO qd; Info: use w/ dabrafenib; give at least 1h before or 2h after meals; do not cut/crush/chew tab

[solution form, 1 yo and older, 8 kg]

Dose: 0.3 mg PO qd; Info: use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, 9-10 kg]

Dose: 0.35 mg PO qd; Info: use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, 11 kg]

Dose: 0.4 mg PO qd; Info: use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, 12-13 kg]

Dose: 0.45 mg PO qd; Info: use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, 14-17 kg]

Dose: 0.55 mg PO qd; Info: use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, 18-21 kg]

Dose: 0.7 mg PO qd; Info: use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, 22-25 kg]

Dose: 0.85 mg PO qd; Info: use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, 26-29 kg]

Dose: 0.9 mg PO qd; Info: use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, 30-33 kg]

Dose: 1 mg PO qd; Info: use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, 34-37 kg]

Dose: 1.15 mg PO qd; Info: use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, 38-41 kg]

Dose: 1.25 mg PO qd; Info: use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, 42-45 kg]

Dose: 1.4 mg PO qd; Info: use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, 46-50 kg]

Dose: 1.6 mg PO qd; Info: use w/ dabrafenib; give at least 1h before or 2h after meals

[solution form, 1 yo and older, >51 kg]

Dose: 2 mg PO qd; Info: use w/ dabrafenib; give at least 1h before or 2h after meals

renal dosing

[see below]

eGFR >15: no adjustment; eGFR <15: not defined

HD/PD: not defined

hepatic dosing

[see below]

bilirubin 1.1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN: not defined