Tafinlar

Adult Dosing .

Dosage forms:  CAP: 50 mg, 75 mg; DISPERSE TAB: 10 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

BRAF V600E- or V600K-positive melanoma

[adjuvant tx]

Dose: 150 mg PO bid for up to 1y; Info: use w/ trametinib; give at least 1h before or 2h after meals; do not open cap

[unresectable or metastatic dz]

Dose: 150 mg PO bid; Info: use w/ trametinib; give at least 1h before or 2h after meals; do not open cap

BRAF V600E-positive melanoma

[unresectable or metastatic dz, monotherapy]

Dose: 150 mg PO bid; Info: give at least 1h before or 2h after meals; do not open cap

BRAF V600E-positive non-small cell lung CA, metastatic

[150 mg PO bid]

Info: use w/ trametinib; give at least 1h before or 2h after meals; do not open cap

BRAF V600E-positive anaplastic thyroid CA, locally advanced or metastatic

[150 mg PO bid]

Info: use w/ trametinib; give at least 1h before or 2h after meals; do not open cap

BRAF V600E-positive solid tumors, unresectable or metastatic

[150 mg PO bid]

Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ trametinib; give at least 1h before or 2h after meals; do not open cap

BRAF V600E-positive glioma, low-grade

[150 mg PO bid]

Info: use w/ trametinib; give at least 1h before or 2h after meals; do not open cap

renal dosing

[see below]

eGFR >15: no adjustment; eGFR <15: not defined

HD/PD: not defined

hepatic dosing

[see below]

bilirubin 1.1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN: not defined

Peds Dosing .

Dosage forms:  CAP: 50 mg, 75 mg; DISPERSE TAB: 10 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

BRAF V600E-positive solid tumors, unresectable or metastatic

[cap form, 1 yo and older, 26-37 kg]

Dose: 75 mg PO bid; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ trametinib; give at least 1h before or 2h after meals; do not open cap

[cap form, 1 yo and older, 38-50 kg]

Dose: 100 mg PO bid; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ trametinib; give at least 1h before or 2h after meals; do not open cap

[cap form, 1 yo and older, >51 kg]

Dose: 150 mg PO bid; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ trametinib; give at least 1h before or 2h after meals; do not open cap

[disperse tab form, 1 yo and older, 8-9 kg]

Dose: 20 mg PO bid; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ trametinib; give at least 1h before or 2h after meals

[disperse tab form, 1 yo and older, 10-13 kg]

Dose: 30 mg PO bid; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ trametinib; give at least 1h before or 2h after meals

[disperse tab form, 1 yo and older, 14-17 kg]

Dose: 40 mg PO bid; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ trametinib; give at least 1h before or 2h after meals

[disperse tab form, 1 yo and older, 18-21 kg]

Dose: 50 mg PO bid; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ trametinib; give at least 1h before or 2h after meals

[disperse tab form, 1 yo and older, 22-25 kg]

Dose: 60 mg PO bid; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ trametinib; give at least 1h before or 2h after meals

[disperse tab form, 1 yo and older, 26-29 kg]

Dose: 70 mg PO bid; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ trametinib; give at least 1h before or 2h after meals

[disperse tab form, 1 yo and older, 30-33 kg]

Dose: 80 mg PO bid; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ trametinib; give at least 1h before or 2h after meals

[disperse tab form, 1 yo and older, 34-37 kg]

Dose: 90 mg PO bid; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ trametinib; give at least 1h before or 2h after meals

[disperse tab form, 1 yo and older, 38-41 kg]

Dose: 100 mg PO bid; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ trametinib; give at least 1h before or 2h after meals

[disperse tab form, 1 yo and older, 42-45 kg]

Dose: 110 mg PO bid; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ trametinib; give at least 1h before or 2h after meals

[disperse tab form, 1 yo and older, 46-50 kg]

Dose: 130 mg PO bid; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ trametinib; give at least 1h before or 2h after meals

[disperse tab form, 1 yo and older, >51 kg]

Dose: 150 mg PO bid; Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ trametinib; give at least 1h before or 2h after meals

BRAF V600E-positive glioma, low-grade

[cap form, 1 yo and older, 26-37 kg]

Dose: 75 mg PO bid; Info: use w/ trametinib; give at least 1h before or 2h after meals; do not open cap

[cap form, 1 yo and older, 38-50 kg]

Dose: 100 mg PO bid; Info: use w/ trametinib; give at least 1h before or 2h after meals; do not open cap

[cap form, 1 yo and older, >51 kg]

Dose: 150 mg PO bid; Info: use w/ trametinib; give at least 1h before or 2h after meals; do not open cap

[disperse tab form, 1 yo and older, 8-9 kg]

Dose: 20 mg PO bid; Info: use w/ trametinib; give at least 1h before or 2h after meals

[disperse tab form, 1 yo and older, 10-13 kg]

Dose: 30 mg PO bid; Info: use w/ trametinib; give at least 1h before or 2h after meals

[disperse tab form, 1 yo and older, 14-17 kg]

Dose: 40 mg PO bid; Info: use w/ trametinib; give at least 1h before or 2h after meals

[disperse tab form, 1 yo and older, 18-21 kg]

Dose: 50 mg PO bid; Info: use w/ trametinib; give at least 1h before or 2h after meals

[disperse tab form, 1 yo and older, 22-25 kg]

Dose: 60 mg PO bid; Info: use w/ trametinib; give at least 1h before or 2h after meals

[disperse tab form, 1 yo and older, 26-29 kg]

Dose: 70 mg PO bid; Info: use w/ trametinib; give at least 1h before or 2h after meals

[disperse tab form, 1 yo and older, 30-33 kg]

Dose: 80 mg PO bid; Info: use w/ trametinib; give at least 1h before or 2h after meals

[disperse tab form, 1 yo and older, 34-37 kg]

Dose: 90 mg PO bid; Info: use w/ trametinib; give at least 1h before or 2h after meals

[disperse tab form, 1 yo and older, 38-41 kg]

Dose: 100 mg PO bid; Info: use w/ trametinib; give at least 1h before or 2h after meals

[disperse tab form, 1 yo and older, 42-45 kg]

Dose: 110 mg PO bid; Info: use w/ trametinib; give at least 1h before or 2h after meals

[disperse tab form, 1 yo and older, 46-50 kg]

Dose: 130 mg PO bid; Info: use w/ trametinib; give at least 1h before or 2h after meals

[disperse tab form, 1 yo and older, >51 kg]

Dose: 150 mg PO bid; Info: use w/ trametinib; give at least 1h before or 2h after meals

renal dosing

[see below]

eGFR >15: no adjustment; eGFR <15: not defined

HD/PD: not defined

hepatic dosing

[see below]

bilirubin 1.1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN: not defined