Injectafer

Adult Dosing .

Dosage forms:  INJ

Special Note

[strength clarification]

Info: 1 mL = 50 mg elemental Fe; doses expressed as elemental Fe

iron deficiency anemia

[<50 kg]

Dose: 15 mg/kg/dose IV x2 doses >7 days apart; Info: for pts w/ non-dialysis dependent CKD or unable to take PO form; may repeat tx course if recurrent iron deficiency anemia

[>50 kg]

Dose: 750 mg IV x2 doses >7 days apart; Max: 1500 mg/tx course; Alt: 15 mg/kg/dose IV x1, max 1000 mg/tx course; Info: for pts w/ non-dialysis dependent CKD or unable to take PO form; may repeat tx course if recurrent iron deficiency anemia

iron deficiency

[<70 kg, Hgb <10]

Dose: 1000 mg IV x1, then 500 mg IV x1 at wk 6; Info: for pts w/ NYHA class II-III heart failure to improve exercise capacity; give 500 mg maintenance dose at wk 12, 24, 36 if serum ferritin <100, or serum ferritin 100-300 w/ transferrin saturation <20%; may repeat tx course if recurrent iron deficiency

[<70 kg, Hgb 10-14]

Dose: 1000 mg IV x1; Info: for pts w/ NYHA class II-III heart failure to improve exercise capacity; give 500 mg maintenance dose at wk 12, 24, 36 if serum ferritin <100, or serum ferritin 100-300 w/ transferrin saturation <20%; may repeat tx course if recurrent iron deficiency

[<70 kg, Hgb 14.1-14.9]

Dose: 500 mg IV x1; Info: for pts w/ NYHA class II-III heart failure to improve exercise capacity; give 500 mg maintenance dose at wk 12, 24, 36 if serum ferritin <100, or serum ferritin 100-300 w/ transferrin saturation <20%; may repeat tx course if recurrent iron deficiency

[>70 kg, Hgb <10]

Dose: 1000 mg IV x1, then 1000 mg IV x1 at wk 6; Info: for pts w/ NYHA class II-III heart failure to improve exercise capacity; give 500 mg maintenance dose at wk 12, 24, 36 if serum ferritin <100, or serum ferritin 100-300 w/ transferrin saturation <20%; may repeat tx course if recurrent iron deficiency

[>70 kg, Hgb 10-14]

Dose: 1000 mg IV x1, then 500 mg IV x1 at wk 6; Info: for pts w/ NYHA class II-III heart failure to improve exercise capacity; give 500 mg maintenance dose at wk 12, 24, 36 if serum ferritin <100, or serum ferritin 100-300 w/ transferrin saturation <20%; may repeat tx course if recurrent iron deficiency

[>70 kg, Hgb 14.1-14.9]

Dose: 500 mg IV x1; Info: for pts w/ NYHA class II-III heart failure to improve exercise capacity; give 500 mg maintenance dose at wk 12, 24, 36 if serum ferritin <100, or serum ferritin 100-300 w/ transferrin saturation <20%; may repeat tx course if recurrent iron deficiency

renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

Special Note

[strength clarification]

Info: 1 mL = 50 mg elemental Fe; doses expressed as elemental Fe

iron deficiency anemia

[1 yo and older, <50 kg]

Dose: 15 mg/kg/dose IV x2 doses >7 days apart; Info: for pts unable to take PO form; may repeat tx course if recurrent iron deficiency anemia

[1 yo and older, >50 kg]

Dose: 750 mg IV x2 doses >7 days apart; Max: 1500 mg/tx course; Alt: 15 mg/kg/dose IV x1, max 1000 mg/tx course; Info: for pts unable to take PO form; may repeat tx course if recurrent iron deficiency anemia

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]