erythromycin base

Adult Dosing .

Dosage forms:  DR CAP: 250 mg; TAB: 250 mg, 500 mg; DR TAB: 250 mg, 333 mg, 500 mg

infections, bacterial

[1000 mg/day PO divided q6-12h]

Max: 4 g/day; Info: consider giving on empty stomach; duration varies w/ infection type, pathogen susceptibility

Legionnaires dz

[500-1000 mg PO q6h x10-21 days]

Info: consider giving on empty stomach

rheumatic fever prophylaxis, secondary

[250 mg PO q12h]

Info: may give on empty stomach

intestinal amebiasis

[1000 mg/day PO divided q6-12h x10-14 days]

Info: not 1st-line agent; consider giving on empty stomach

infection prophylaxis, colorectal surgery

[dosing protocols may vary]

Dose: 1000 mg PO at 1pm, 2pm, and 11pm the day before 8am surgery; Info: give w/ neomycin sulfate; use w/ mechanical bowel prep; follow w/ appropriate preop IV antibiotic prophylaxis

chancroid (off-label)

[500 mg PO q8h x7 days]

Info: consider giving on empty stomach

lymphogranuloma venereum (off-label)

[500 mg PO q6h x21 days]

Info: not 1st-line agent; consider giving on empty stomach

granuloma inguinale (off-label)

[500 mg PO q6h for at least 3wk]

Info: may extend tx if not healed after 3wk; not 1st-line agent; consider giving on empty stomach

gastroparesis (off-label)

[250-500 mg PO q8h]

Info: give 30min qac; may require initial IV tx

pertussis (off-label)

[500 mg PO q6h x14 days]

Info: consider giving on empty stomach

COPD exacerbation risk reduction (off-label)

[250 mg PO bid]

Info: for pts w/ exacerbation hx; consider giving on empty stomach; search 'gold' for epocrates COPD GOLD decision tools

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  DR CAP: 250 mg; TAB: 250 mg, 500 mg; DR TAB: 250 mg, 333 mg, 500 mg

infections, bacterial

[infants/children]

Dose: 30-50 mg/kg/day PO divided q6-8h; Max: 4 g/day; Info: consider giving on empty stomach; may incr. to 60-100 mg/kg/day PO divided q6-8h if severe infection, max 4 g/day; dose, duration varies w/ infection type, pathogen susceptibility

pertussis

[<1 mo (off-label)]

Dose: 40-50 mg/kg/day PO divided q6h x14 days; Info: not 1st-line agent; consider giving on empty stomach

[1 mo and older]

Dose: 40-50 mg/kg/day PO divided q6h x14 days; Max: 2 g/day; Info: consider giving on empty stomach

community-acquired pneumonia, atypical

[>3 mo]

Dose: 40 mg/kg/day PO divided q6h x7-10 days; Info: consider giving on empty stomach

rheumatic fever prophylaxis, secondary

[children]

Dose: 250 mg PO q12h; Info: consider giving on empty stomach

intestinal amebiasis

[children]

Dose: 30-50 mg/kg/day PO divided q6-8h x10-14 days; Max: 4 g/day; Info: not 1st-line agent; consider giving on empty stomach

infections, chlamydial

[preadolescents <45 kg]

Dose: 50 mg/kg/day PO divided q6h x14 days; Max: 2 g/day; Info: 1st-line agent; consider giving on empty stomach

infection prophylaxis, colorectal surgery

[dosing protocols may vary]

Dose: 20 mg/kg/dose PO at 1pm, 2pm, and 11pm the day before 8am surgery; Max: 1000 mg/dose; Info: give w/ neomycin sulfate; use w/ mechanical bowel prep; follow w/ appropriate preop IV antibiotic prophylaxis

GI dysmotility (off-label)

[children]

Dose: 10-20 mg/kg/day PO divided q6-8h; Info: use after IV tx; give 30min qac if q8h; give 30min qac and qhs if q6h

chancroid (off-label)

[preadolescents >45 kg and adolescents]

Dose: 500 mg PO q8h x7 days; Info: consider giving on empty stomach

lymphogranuloma venereum (off-label)

[adolescents]

Dose: 500 mg PO q6h x21 days; Info: not 1st-line agent; consider giving on empty stomach

granuloma inguinale (off-label)

[adolescents]

Dose: 500 mg PO q6h for at least 3wk; Info: may extend tx if not healed after 3wk; not 1st-line agent; consider giving on empty stomach

renal dosing

[see below]

CrCl <10: decr. usual dose by 25-50% or decr. usual frequency

HD: decr. usual dose by 25-50% or decr. usual frequency; no supplement after dialysis; PD: decr. usual dose by 25-50% or decr. usual frequency; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised