erythromycin ethylsuccinate

Adult Dosing .

Dosage forms:  TAB: 400 mg; SUSP: 200 mg per 5 mL, 400 mg per 5 mL

infections, bacterial

[1600 mg/day PO divided q6-12h]

Max: 4 g/day

intestinal amebiasis

[400 mg PO q6h x10-14 days]

Info: not 1st-line agent

rheumatic fever prophylaxis, secondary

[400 mg PO q12h]

gastroparesis (off-label)

[250-500 mg PO q8h]

Info: give 30min qac; may require initial IV tx

pertussis (off-label)

[500 mg PO q6h x14 days]

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  TAB: 400 mg; SUSP: 200 mg per 5 mL, 400 mg per 5 mL

infections, bacterial

[infants/children]

Dose: 30-50 mg/kg/day PO divided q6-8h; Max: 4 g/day

pertussis

[<1 mo (off-label)]

Dose: 40-50 mg/kg/day PO divided q6h x14 days; Info: not 1st-line agent

[1 mo and older]

Dose: 40-50 mg/kg/day PO divided q6h x14 days; Max: 2 g/day

community-acquired pneumonia, atypical

[>3 mo]

Dose: 40 mg/kg/day PO divided q6h x7-10 days

intestinal amebiasis

[children]

Dose: 30-50 mg/kg/day PO divided q6-8h x10-14 days; Max: 4 g/day; Info: not 1st-line agent

rheumatic fever prophylaxis, secondary

[400 mg PO q12h]

infections, chlamydial

[preadolescents <45 kg]

Dose: 50 mg/kg/day PO divided q6h x14 days; Info: 1st-line agent

GI dysmotility (off-label)

[children]

Dose: 10-20 mg/kg/day PO divided q6-8h; Info: use after IV tx; give 30min qac if q8h; give 30min qac and qhs if q6h

renal dosing

[see below]

CrCl <10: decr. usual dose by 25-50% or decr. usual frequency

HD: decr. usual dose by 25-50% or decr. usual frequency; no supplement after dialysis; PD: decr. usual dose by 25-50% or decr. usual frequency; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised