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Edecrin
ethacrynic acid
Black Box Warnings .
Fluid and Electrolyte Depletion
potent diuretic in excessive amts can cause profound diuresis w/ water/electrolyte depletion; individualize dose and schedule w/ medical supervision
Adult Dosing .
Dosage forms: TAB: 25 mg; INJ: various
edema
- [PO route]
- Dose: 50-100 mg PO qd-bid; Start: 50 mg PO qd, incr. 25-50 mg/day; Max: 400 mg/day; Info: for pts w/ CHF, hepatic dz or renal dz; maint. dose may be given intermittently
- [IV route]
- Dose: 50 mg IV x1; Max: 100 mg/dose; Alt: 0.5-1 mg/kg/dose IV x1; Info: for pts w/ CHF, hepatic dz or renal dz; may repeat dose x1
ascites, short-term tx
- [PO route]
- Dose: 50-100 mg PO qd-bid; Start: 50 mg PO qd, incr. 25-50 mg/day; Max: 400 mg/day; Info: for pts w/ malignancy, idiopathic edema or lymphedema
- [IV route]
- Dose: 50 mg IV x1; Max: 100 mg/dose; Alt: 0.5-1 mg/kg/dose IV x1; Info: for pts w/ malignancy, idiopathic edema or lymphedema; may repeat dose x1
HTN (off-label)
- [25-100 mg/day PO divided qd-tid]
- Start: 25 mg PO qd; Max: 100 mg/day
renal dosing
- [see below]
- renal impairment: not defined; anuria: contraindicated; Info: caution advised if severe impairment
- HD/PD: not defined
hepatic dosing
- [see below]
- advanced cirrhosis: not defined, caution advised
Peds Dosing .
- Dosage forms: TAB: 25 mg
edema, short-term tx
- [2 yo and older]
- Start: 25 mg PO qd, incr. 25 mg/day q2-3 days; Max: 3 mg/kg/day; Alt: 1 mg/kg/dose PO qd; Info: for hospitalized pts w/ congenital heart dz or nephrotic syndrome
renal dosing
- [see below]
- renal impairment: not defined; anuria: contraindicated; Info: caution advised if severe impairment
- HD/PD: not defined
hepatic dosing
- [see below]
- advanced cirrhosis: not defined, caution advised