venlafaxine

Adult Dosing .

Dosage forms:  ER CAP: 37.5 mg, 75 mg, 150 mg; TAB: 25 mg, 37.5 mg, 50 mg, 75 mg, 100 mg; ER TAB: 37.5 mg, 75 mg, 112.5 mg, 150 mg, 225 mg

major depressive disorder

[immediate-release form]

Dose: 75-225 mg/day PO divided bid-tid; Start: 75 mg/day PO divided bid-tid, may incr. by up to 75 mg/day no more frequently than q4 days; Max: 375 mg/day; Info: give w/ food; taper dose over 2wk to D/C

[extended-release form]

Dose: 75-225 mg ER PO qd; Start: 37.5-75 mg ER PO qd, may incr. by up to 75 mg/day no more frequently than q4 days; Max: 225 mg/day ER; Info: give w/ food; may open ER cap, but do not cut/crush/chew/dissolve contents; do not cut/crush/chew/dissolve ER tab; taper dose by no more than 75 mg/wk to D/C

generalized anxiety disorder

[75-225 mg ER PO qd]

Start: 37.5-75 mg ER PO qd, may incr. by up to 75 mg/day no more frequently than q4 days; Max: 225 mg/day ER; Info: give w/ food; may open ER cap, but do not cut/crush/chew/dissolve contents; do not cut/crush/chew/dissolve ER tab; taper dose by no more than 75 mg/wk to D/C

social anxiety disorder

[75 mg ER PO qd]

Info: no proven additional benefit at doses >75 mg/day; give w/ food; may open ER cap, but do not cut/crush/chew/dissolve contents; do not cut/crush/chew/dissolve ER tab

panic disorder

[75-225 mg ER PO qd]

Start: 37.5 mg ER PO qd x7 days, then 75 mg ER PO qd x7 days, then may incr. by up to 75 mg/day no more frequently than q7 days; Max: 225 mg/day ER; Info: give w/ food; may open ER cap, but do not cut/crush/chew dissolve contents; do not cut/crush/chew/dissolve ER tab; taper dose by no more than 75 mg/wk to D/C

migraine prophylaxis (off-label)

[150 mg ER PO qd]

Start: 37.5 mg ER PO qd, incr. dose q3 days; Max: 150 mg/day ER; Info: give w/ food; may open ER cap, but do not cut/crush/chew/dissolve contents; do not cut/crush/chew/dissolve ER tab; taper dose by no more than 75 mg/wk to D/C

post-traumatic stress disorder (off-label)

[37.5-300 mg ER PO qd]

Start: 37.5 mg ER PO qd, may incr. by 75 mg/day q4-7 days; Max: 375 mg/day ER; Info: give w/ food; may open ER cap, but do not cut/crush/chew/dissolve contents; do not cut/crush/chew/dissolve ER tab; taper dose by no more than 75 mg/wk to D/C

neuropathic pain, diabetic (off-label)

[75-225 mg ER PO qd]

Start: 37.5 mg ER PO qd x7 days, then 75 mg ER PO qd x7 days, then may incr. by 75 mg/day q7 days; Max: 225 mg/day ER; Info: give w/ food; may open ER cap, but do not cut/crush/chew/dissolve contents; do not cut/crush/chew/dissolve ER tab; taper dose by no more than 75 mg/wk to D/C

cataplexy (off-label)

[75-300 mg ER PO qd]

Start: 37.5 mg ER PO qd, may incr. by 75 mg/day q4-7 days; Max: 375 mg/day ER; Info: give w/ food; may open ER cap, but do not cut/crush/chew/dissolve contents; do not cut/crush/chew/dissolve ER tab; taper dose by no more than 75 mg/wk to D/C

vasomotor sx, mod-severe menopausal (off-label)

[37.5-150 mg ER PO qd]

Start: 37.5 mg ER PO qd, may incr. dose q7 days; Info: give w/ food; may open ER cap, but do not cut/crush/chew/dissolve contents; do not cut/crush/chew/dissolve ER tab; taper dose by no more than 75 mg/wk to D/C

renal dosing

[adjust dose amount]

CrCl 30-89: decr. usual dose by 25-50%; CrCl <30: decr. usual dose by at least 50%

HD: decr. usual dose by at least 50%; no supplement after dialysis; PD: decr. usual dose by 50%; no supplement

hepatic dosing

[adjust dose amount]

Child-Pugh Class A or B: decr. usual dose by 50%; Child-Pugh Class C or cirrhosis: decr. usual dose by at least 50%

Peds Dosing .

Dosage forms:  ER CAP: 37.5 mg, 75 mg, 150 mg; TAB: 25 mg, 37.5 mg, 50 mg, 75 mg, 100 mg; ER TAB: 37.5 mg, 75 mg, 112.5 mg, 150 mg, 225 mg

major depressive disorder (off-label)

[12 yo and older]

Dose: 37.5-150 mg ER PO qd; Start: 37.5 mg ER PO qd, may incr. by 37.5 mg/day ER qwk; Max: 225 mg/day; Info: not 1st line tx; give w/ food; may open ER cap, but do not cut/crush/chew/dissolve contents; do not cut/crush/chew/dissolve ER tab; taper dose by no more than 75 mg/wk to D/C

generalized anxiety disorder (off-label)

[7 yo and older]

Dose: 75-225 mg ER PO qd; Start: 37.5 mg ER PO qd, incr. by 37.5 mg/day ER q4-7 days; Info: give w/ food; may open ER cap, but do not cut/crush/chew/dissolve contents; do not cut/crush/chew/dissolve ER tab; taper dose by no more than 75 mg/wk to D/C

ADHD (off-label)

[6 yo and older]

Dose: 50-75 mg/day PO divided tid; Start: 12.5-25 mg/day PO divided bid-tid x7 days, incr. by 25 mg/day q7 days; Max: 150 mg/day; Info: give w/ food; taper dose over 2wk to D/C

cataplexy (off-label)

[5 yo and older]

Dose: 37.5-150 mg ER PO qd; Start: 37.5 mg ER PO qd, may incr. by 37.5 mg/day q4-7 days; Max: 300 mg/day ER; Info: give w/ food; may open ER cap, but do not cut/crush/chew/dissolve contents; do not cut/crush/chew/dissolve ER tab; taper dose by no more than 75 mg/wk to D/C

renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance