Select a medication above to begin.
Duavee
estrogens, conjugated/ bazedoxifene
Black Box Warnings .
Endometrial Cancer Risk
unopposed estrogen use incr. endometrial CA risk in pts w/ intact uterus; estrogens, conjugated/bazedoxifene has been shown to decr. risk of endometrial hyperplasia, a possible precursor to endometrial CA; use adequate diagnostic measures such as endometrial sampling to rule out malignancy if undiagnosed persistent or recurrent abnormal genital bleeding; pts should not take additional estrogens during tx
Cardiovascular and Probable Dementia Risks
estrogen should not be used for cardiovascular dz or dementia prevention; incr. risk of stroke and DVT in postmenopausal women 50-79 yo (WHI estrogen-alone substudy regimen = conjugated estrogens 0.625 mg/day x7y); incr. risk of probable dementia in postmenopausal women 65 yo and older (WHIMS estrogen-alone substudy regimen = conjugated estrogens 0.625 mg/day x5y); risk unknown in younger postmenopausal women; other doses of conjugated estrogens or other estrogen-alone products not studied, therefore adverse cardiovascular events and dementia relevance is unknown; weigh risk/benefit; use lowest effective estrogen dose, shortest duration based on individual tx goals and risks
Adult Dosing .
Dosage forms: TAB: 0.45 mg/20 mg
vasomotor sx, mod-severe menopausal
- [1 tab PO qd]
- Info: for women w/ intact uterus; use shortest effective tx duration; do not cut/crush/chew tab; D/C tx >4-6wk before surgery w/ VTE risk
osteoporosis prevention, postmenopausal
- [1 tab PO qd]
- Info: for women w/ intact uterus; use shortest effective tx duration; calcium and vitamin D supplementation recommended if inadequate dietary intake; do not cut/crush/chew tab; D/C tx >4-6wk before surgery w/ VTE risk
renal dosing
- [see below]
- renal dz: not defined, caution advised
- HD/PD: not defined, caution advised
hepatic dosing
- [see below]
- hepatic impairment: contraindicated
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.