Aptiom

Adult Dosing .

Dosage forms:  TAB: 200 mg, 400 mg, 600 mg, 800 mg

partial seizures

[800-1600 mg PO qd]

Start: 400 mg PO qd, incr. by 400-600 mg/day qwk; Max: 1600 mg/day; Info: for monotherapy and adjunct tx; may start 800 mg PO qd if benefit outweighs risk; taper dose gradually to D/C

renal dosing

[adjust dose amount]

CrCl <50: decr. usual dose by 50%

HD/PD: not defined

hepatic dosing

[see below]

mild-moderate impairment: no adjustment; severe impairment: not defined

Peds Dosing .

Dosage forms:  TAB: 200 mg, 400 mg, 600 mg, 800 mg

partial seizures

[4-17 yo, 11-21 kg]

Dose: 400-600 mg PO qd; Start: 200 mg PO qd, may incr. by up to 200 mg/day no more frequently than qwk; Max: 600 mg/day; Info: for monotherapy and adjunct tx; taper dose gradually to D/C

[4-17 yo, 22-31 kg]

Dose: 500-800 mg PO qd; Start: 300 mg PO qd, may incr. by up to 300 mg/day no more frequently than qwk; Max: 800 mg/day; Info: for monotherapy and adjunct tx; taper dose gradually to D/C

[4-17 yo, 32-38 kg]

Dose: 600-900 mg PO qd; Start: 300 mg PO qd, may incr. by up to 300 mg/day no more frequently than qwk; Max: 900 mg/day; Info: for monotherapy and adjunct tx; taper dose gradually to D/C

[4-17 yo, >38 kg]

Dose: 800-1200 mg PO qd; Start: 400 mg PO qd, may incr. by up to 400 mg/day no more frequently than qwk; Max: 1200 mg/day; Info: for monotherapy and adjunct tx; taper dose gradually to D/C

renal dosing

[adjust dose amount]

CrCl <50: decr. usual dose by 50%

HD/PD: not defined

hepatic dosing

[see below]

mild-moderate impairment: no adjustment; severe impairment: not defined