Purixan

Adult Dosing .

Dosage forms:  SUSP: 20 mg per mL

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

ALL

[induction tx (off-label)]

Dose: 2.5-5 mg/kg/dose PO qd; Start: 2.5 mg/kg/dose PO qd, may incr. to 5 mg/kg/dose PO qd after 4wk; Alt: 100-200 mg PO qd; Info: decr. dose if TPMT and/or nucleotide diphosphatase (NUDT15) heterozygous deficiency; decr. dose by at least 90% if TPMT or NUDT15 homozygous deficiency

[maintenance tx]

Dose: 1.5-2.5 mg/kg/dose PO qd; Alt: 50-75 mg/m^2/dose PO qd; Info: use w/ methotrexate or other agents for remission maintenance; decr. dose if TPMT and/or nucleotide diphosphatase (NUDT15) heterozygous deficiency; decr. dose by at least 90% if TPMT or NUDT15 homozygous deficiency

Crohn dz (off-label)

[75-125 mg PO qd]

Start: 50 mg PO qd; Max: 1.5 mg/kg/day; Info: for induction or remission maintenance in mod-severe or chronically active Crohn dz or fistulizing Crohn dz tx; decr. dose if TPMT and/or nucleotide diphosphatase (NUDT15) heterozygous deficiency; decr. dose by at least 90% if TPMT or NUDT15 homozygous deficiency

ulcerative colitis (off-label)

[75-125 mg PO qd]

Start: 50 mg PO qd; Max: 1.5 mg/kg/day; Info: for induction or remission maintenance; decr. dose if TPMT and/or nucleotide diphosphatase (NUDT15) heterozygous deficiency; decr. dose by at least 90% if TPMT or NUDT15 homozygous deficiency

renal dosing

[adjust dose amount, frequency]

CrCl <50: give usual dose q36-48h; Alt: use lowest usual start dose

HD/PD: not defined

hepatic dosing

[adjust dose amount]

hepatic impairment: use lowest usual start dose

Peds Dosing .

Dosage forms:  SUSP: 20 mg per mL

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

ALL

[induction tx (off-label)]

Dose: 2.5-5 mg/kg/dose PO qd; Start: 2.5 mg/kg/dose PO qd, may incr. to 5 mg/kg/dose PO qd after 4wk; Info: decr. dose if TPMT and/or nucleotide diphosphatase (NUDT15) heterozygous deficiency; decr. dose by at least 90% if TPMT or NUDT15 homozygous deficiency

[maintenance tx]

Dose: 1.5-2.5 mg/kg/dose PO qd; Alt: 50-75 mg/m^2/dose PO qd; Info: use w/ methotrexate or other agents for remission maintenance; decr. dose if TPMT and/or nucleotide diphosphatase (NUDT15) heterozygous deficiency; decr. dose by at least 90% if TPMT or NUDT15 homozygous deficiency

renal dosing

[adjust dose frequency]

CrCl <50: give usual dose q48h

HD: give usual dose q48h, on dialysis days admin. after dialysis; no supplement; PD: give usual dose q48h; no supplement

hepatic dosing

[adjust dose amount]

hepatic impairment: use lowest usual start dose