Ryanodex

Adult Dosing .

Dosage forms:  INJ

malignant hyperthermia, acute

[2.5 mg/kg/dose IV prn up to 10 mg/kg, then 1 mg/kg/dose IV q4-6h for at least 24h]

Info: initial doses >10mg/kg/dose may be required for pts w/ persistent sx

neuroleptic malignant syndrome (off-label)

[1 mg/kg/dose IV q6h]

Start: 1-2.5 mg/kg/dose IV x1; Max: 10 mg/kg/day; Info: when pt stable, may switch to 4-8 mg/kg/day PO divided qid x7-10 days

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

malignant hyperthermia, acute

[2.5 mg/kg/dose IV prn up to 10 mg/kg, then 1 mg/kg/dose IV q4-6h for at least 24h]

Info: initial doses >10mg/kg/dose may be required for pts w/ persistent sx

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]