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Contrave
naltrexone/ bupropion hydrochloride
Black Box Warnings .
Suicidality
not indicated for major depressive or other psychiatric disorders, but bupropion under other trade names indicated for this use; incr. risk of suicidality in children, adolescents and young adults w/ major depressive or other psychiatric disorders esp. during 1st months of tx w/ antidepressants vs. placebo; weigh risk vs. benefit; in short-term studies of antidepressants vs. placebo, suicidality risk not incr. in pts >24 yo, and risk decr. in pts 65 yo and older; observe all pts for clinical worsening, suicidality, or unusual behavior changes; not approved for peds use
Adult Dosing .
Dosage forms: ER TAB: 8 mg/90 mg
weight management, chronic
- [2 tabs PO bid]
- Start: 1 tab PO qam x1wk, then 1 tab PO bid x1wk, then 2 tabs PO qam and 1 tab PO qpm x1wk; Max: 4 tabs/day; Info: for pts w/ BMI >30 kg/m^2 or >27 kg/m^2 w/ wt-related comorbidity; D/C if wt loss <5% after 12wk on max dose; do not cut/crush/chew tab; avoid admin. w/ high fat meal
renal dosing
- [see below]
- mod-severe impairment: max 1 tab bid; ESRD: avoid use
- HD/PD: not defined
hepatic dosing
- [adjust dose amount, frequency]
- hepatic impairment: max 1 tab qam
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.