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Trulicity
dulaglutide
Black Box Warnings .
Thyroid C-cell Tumor Risk
contraindicated in pts w/ medullary thyroid carcinoma (MTC) hx or family hx, or in pts w/ multiple endocrine neoplasia syndrome type 2 (MEN 2); dose-related and duration-dependent incr. in thyroid C-cell tumor incidence observed in rodents, but human relevance unknown; uncertain value of routine serum calcitonin or thyroid ultrasound monitoring; advise pts of potential MTC risk and thyroid tumor sx (e.g., neck mass, dysphagia, dyspnea, persistent hoarseness)
Adult Dosing .
Dosage forms: INJ (pen): 0.75 mg per injection, 1.5 mg per injection, 3 mg per injection, 4.5 mg per injection
diabetes mellitus, type 2
- [0.75-4.5 mg SC qwk]
- Start: 0.75 mg SC qwk x4wk, then may incr. to 1.5 mg SC qwk x4wk, then may incr. by 1.5 mg/wk no more frequently than q4wk; Max: 4.5 mg/wk; Info: give doses >72h apart
cardiovascular event risk reduction (DM type 2 pts w/ estab. cardiovascular dz or multiple cardiovascular risk factors)
- [0.75-4.5 mg SC qwk]
- Start: 0.75 mg SC qwk x4wk, then may incr. to 1.5 mg SC qwk x4wk, then may incr. by 1.5 mg/wk no more frequently than q4wk if additional glycemic control needed; Max: 4.5 mg/wk; Info: give doses >72h apart
renal dosing
- [see below]
- renal impairment: no adjustment; Info: caution advised if ESRD
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: INJ (pen): 0.75 mg per injection, 1.5 mg per injection, 3 mg per injection, 4.5 mg per injection
diabetes mellitus, type 2
- [10 yo and older]
- Dose: 0.75-1.5 mg SC qwk; Start: 0.75 mg SC qwk x4wk, then may incr. to 1.5 mg SC qwk; Max: 1.5 mg/wk; Info: give doses >72h apart
renal dosing
- [see below]
- renal impairment: no adjustment; Info: caution advised if ESRD
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised