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Afrezza
insulin inhaled
Black Box Warnings .
Acute Bronchospasm Risk
contraindicated in chronic pulmonary dz pts such as asthma or COPD; acute bronchospasm observed in asthma and COPD pts; before tx start, assess all pts for potential pulmonary dz incl. hx, physical exam, and spirometry (FEV1)
Adult Dosing .
Dosage forms: 4-unit convenience pack; 8-unit convenience pack; 12-unit convenience pack; 4-unit and 8-unit convenience pack; 8-unit and 12-unit convenience pack; 4-unit and 8-unit and 12-unit convenience pack
Special Note
- [4-unit convenience pack components]
- Info: pack contains 4-unit (blue) DPI cartridge x90
- [8-unit convenience pack components]
- Info: pack contains 8-unit (green) DPI cartridge x90
- [12-unit convenience pack components]
- Info: pack contains 12-unit (yellow) DPI cartridge x90
- [4-unit and 8-unit convenience pack components]
- Info: pack contains 4-unit (blue) DPI cartridge x90 and 8-unit (green) DPI cartridge x90
- [8-unit and 12-unit convenience pack components]
- Info: pack contains 8-unit (green) DPI cartridge x90 and 12-unit (yellow) DPI cartridge x90
- [4-unit and 8-unit and 12-unit convenience pack components]
- Info: pack contains 4-unit (blue) DPI cartridge x60 and 8-unit (green) DPI cartridge x60 and 12-unit (yellow) DPI cartridge x60
- [additional info]
- Info: search Insulin Product Comparisons for comparison of onset, peak, duration, dosage form, and mixing compatibility
diabetes mellitus
- [insulin-naive pts]
- Dose: individualize dose inhaled immediately before each meal; Start: 4 units inhaled immediately before each meal; Info: consider D/C tx if FEV1 decr. >20% from baseline; dose adjustment may be needed during pregnancy and/or immed. postpartum; onset 0.2h, peak 0.6-0.9h, duration 1.5-4.5h (rapid-acting insulin)
- [insulin-experienced pts]
- Dose: individualize dose inhaled immediately before each meal; Start: individualize dose based on current prandial SC insulin intake, see pkg insert for conversion; Info: consider D/C tx if FEV1 decr. >20% from baseline; dose adjustment may be needed during pregnancy and/or immed. postpartum; onset 0.2h, peak 0.6-0.9h, duration 1.5-4.5h (rapid-acting insulin)
renal dosing
- [see below]
- renal impairment: consider decr. usual start dose
- HD/PD: consider decr. usual start dose; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.