Ibrance

Adult Dosing .

Dosage forms:  CAP: 75 mg, 100 mg, 125 mg; TAB: 75 mg, 100 mg, 125 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

hormone receptor-positive HER2-negative breast CA, advanced or metastatic

[initial tx]

Dose: 125 mg PO qd on days 1-21 of 28-day cycle; Info: use w/ aromatase inhibitor; give w/ LHRH agonist in pre/perimenopausal female pts; consider giving w/ LHRH agonist in male pts; give caps w/ food; do not open cap; do not cut/crush/chew tab

[progressive dz]

Dose: 125 mg PO qd on days 1-21 of 28-day cycle; Info: use w/ fulvestrant; give w/ LHRH agonist in pre/perimenopausal female pts; give caps w/ food; do not open cap; do not cut/crush/chew tab

renal dosing

[see below]

CrCl >15: no adjustment; CrCl <15: not defined

HD/PD: not defined

hepatic dosing

[adjust dose amount]

Child-Pugh Class C: 75 mg qd on days 1-21 of 28-day cycle

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.