Rytary

Adult Dosing .

Dosage forms:  ER CAP: 23.75 mg/95 mg, 36.25 mg/145 mg, 48.75 mg/195 mg, 61.25 mg/245 mg

Special Note

[formulation clarification]

Info: carbidopa/levodopa ER cap not interchangeable w/ ER tab; do not substitute on a mg to mg basis; may interchange w/ other ER cap at approx. mg to mg basis

parkinsonism

[levodopa-naive pts]

Dose: individualize dose PO tid; Start: 23.75 mg/95 mg PO tid x3 days, may incr. to 36.25 mg/145 mg PO tid on day 4, then may incr. to 97.5 mg/390 mg PO tid; Max: 612.5 mg/2450 mg per day; Info: dosing frequency may be incr. from tid to 5x/day if needed; use lowest effective dose; may open cap, but do not crush/chew contents; taper dose gradually to D/C

[conversion from IR levodopa 400-549 mg/day]

Dose: individualize dose PO tid; Start: 3 caps (23.75 mg/95 mg) PO tid; Max: 612.5 mg/2450 mg per day; Info: titrate dose to optimal effect; dosing frequency may be incr. from tid to 5x/day if needed; use lowest effective dose; may open cap, but do not crush/chew contents; taper dose gradually to D/C

[conversion from IR levodopa 550-749 mg/day]

Dose: individualize dose PO tid; Start: 4 caps (23.75 mg/95 mg) PO tid; Max: 612.5 mg/2450 mg per day; Info: titrate dose to optimal effect; dosing frequency may be incr. from tid to 5x/day if needed; use lowest effective dose; may open cap, but do not crush/chew contents; taper dose gradually to D/C

[conversion from IR levodopa 750-949 mg/day]

Dose: individualize dose PO tid; Start: 3 caps (36.25 mg/145 mg) PO tid; Max: 612.5 mg/2450 mg per day; Info: titrate dose to optimal effect; dosing frequency may be incr. from tid to 5x/day if needed; use lowest effective dose; may open cap, but do not crush/chew contents; taper dose gradually to D/C

[conversion from IR levodopa 950-1249 mg/day]

Dose: individualize dose PO tid; Start: 3 caps (48.75 mg/195 mg) PO tid; Max: 612.5 mg/2450 mg per day; Info: titrate dose to optimal effect; dosing frequency may be incr. from tid to 5x/day if needed; use lowest effective dose; may open cap, but do not crush/chew contents; taper dose gradually to D/C

[conversion from IR levodopa 1250 mg/day or greater]

Dose: individualize dose PO tid; Start: 4 caps (48.75 mg/195 mg) PO tid or 3 caps (61.25 mg/245 mg) PO tid; Max: 612.5 mg/2450 mg per day; Info: titrate dose to optimal effect; dosing frequency may be incr. from tid to 5x/day if needed; use lowest effective dose; may open cap, but do not crush/chew contents; taper dose gradually to D/C

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.