Bexsero

Adult Dosing .

Dosage forms:  INJ

Special Note

[formulation clarification]

Info: not interchangeable w/ meningococcal group B vaccine (recombinant) (MenB-FHbp); if doses from different MenB products used, then series must be restarted w/ one product

invasive meningococcal dz prevention

[18-25 yo, pts w/ low infection risk]

Dose: 0.5 mL IM x2 doses at least 1mo apart; Info: for healthy pts 16-23 yo based on shared clinical decision-making, preferred in pts 16-18 yo; search 'immunization' for epocrates Adult Immunization decision tool incl. links to CDC/ACIP schedules

[18-25 yo, pts w/ high infection risk]

Dose: 0.5 mL IM x2 doses at least 1mo apart; Info: for pts w/ asplenia, sickle cell dz, persistent complement component deficiency, pts on complement inhibitor tx, lab workers exposed to N. meningitidis; give booster 1y after primary series, then q2-3y if continued risk; search 'immunization' for epocrates Adult Immunization decision tool incl. links to CDC/ACIP schedules

[26 yo and older, pts w/ high infection risk (off-label)]

Dose: 0.5 mL IM x2 doses at least 1mo apart; Info: for pts w/ asplenia, sickle cell dz, persistent complement component deficiency, pts on complement inhibitor tx, lab workers exposed to N. meningitidis; give booster 1y after primary series, then q2-3y if continued risk; search 'immunization' for epocrates Adult Immunization decision tool incl. links to CDC/ACIP schedules

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[no adjustment]

Peds Dosing .

Dosage forms:  INJ

Special Note

[formulation clarification]

Info: not interchangeable w/ meningococcal group B vaccine (recombinant) (MenB-FHbp); if doses from different MenB products used, then series must be restarted w/ one product

invasive meningococcal dz prevention

[10-17 yo, pts w/ low infection risk]

Dose: 0.5 mL IM x2 doses at least 1mo apart; Info: for healthy pts 16-23 yo based on shared clinical decision-making, preferred in pts 16-18 yo; search 'immunization' for epocrates Child/Adolescent Immunization decision tool incl. links to CDC/ACIP schedules

[10-17 yo, pts w/ high infection risk]

Dose: 0.5 mL IM x2 doses at least 1mo apart; Info: for asplenia, persistent complement component deficiency, pts on complement inhibitor tx; give booster 1y after primary series, then q2-3y if continued risk; search 'immunization' for epocrates Child/Adolescent Immunization decision tool incl. links to CDC/ACIP schedules

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[no adjustment]